The applications of flexible electronics in dental,oral,and craniofacial medicine  

作　　者：Kang-Ning Wang Zi-Zhan Li Ze-Min Cai Lei-Ming Cao Nian-Nian Zhong Bing Liu Kan Zhou Fang-Yi Huo Bo Cai Lin-Lin Bu 

机构地区：[1]State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,Department of Oral&Maxillofacial—Head Neck Oncology,School&Hospital of Stomatology,Wuhan University,Wuhan 430079,China [2]Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances,School of Environment and Health,Jianghan University,Wuhan 430056,China [3]Department of Zhuankou Clinical Branches,School&Hospital of Stomatology,Wuhan University,Wuhan 430000,China

出　　处：《npj Flexible Electronics》2024年第1期577-590,共14页npj-柔性电子(英文)

基　　金：supported by China Postdoctoral Science Foundation(2018M630883 and 2019T120688);Hubei Province Chinese Medicine Research Project(ZY2023Q015);Natural Science Foundation of China(61904057 and 22193051);Hubei Province(2023AFB665 and 2018CFB124);Fundamental Research Funds for the Central Universities(Wuhan University,Clinical Medicine+X,2042024YXB017),Medical Young Talents Program of Hubei Province and Wuhan Young Medical Talents Training Project.

摘　　要：Dental,oral,and craniofacial diseases jeopardize health and reduce the quality of life.Accessing disease-related signals in advance is beneficial to prevent the occurrence or progression of those diseases.However,the inconvenience of periodical in-hospital examinations and the difficulty of sustaining daily health monitoring challenge personal compliance and possibly lead to limited prevention or treatment.Medical flexible electronics are electric devices fabricated on soft and extensible substrates to fit the human skin and enable non-invasive continuous monitoring of biophysical/biochemical signals.They provide the possibility of long-term,continuous,comfortable,and wireless healthcare monitoring and are expected to alleviate time and economic consumption by avoiding in-hospital examinations and treatment.Therefore,flexible electronics have emerged for early diagnosis and disease monitoring in stomatology.It is noteworthy that special biophysical/biochemical characteristics and the environment of dental,oral,and craniofacial areas bring distinct challenges that flexible electronics need to address ingeniously to ensure their stability,selectivity,and sensitivity.This review summaries flexible electronics and their specificity when used in dental,oral,and craniofacial applications,including monitoring saliva or cavity-gas related biosignals,sensing the mechanical fluctuation from facial muscle/respiratory activities or orthodontic forces,and executing special functions in the prevention or postoperative recovery of relevant diseases.Furthermore,after analyzing current challenges and proposing potential solutions,the“5I”principles of imperceptibility,intelligence,individualization,integration,and inexpensiveness are presented to help guide the future development of flexible electronics and promote their commercialization for dental,oral,and craniofacial medicine.

关 键 词：PREVENTION ELECTRONICS enable 

分 类 号：R78[医药卫生—口腔医学]