唾液腺肿瘤诊治研究进展  

Research progress in diagnosis and treatment of salivary gland tumors

作　　者：俞光岩[1] 彭歆[1] 高敏[1] 叶鹏 葛娜[1] 贾梦琪 李炳雨 唐祖南 胡耒豪 章文博[1] YU Guangyan;PENG Xin;GAO Min;YE Peng;GE Na;JIA Mengqi;LI Bingyu;TANG Zunan;HU Leihao;ZHANG Wenbo(Department of Oral&Maxillofacial Surgery,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology,Beijing 100081,China)

机构地区：[1]北京大学口腔医学院·口腔医院口腔颌面外科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,口腔数字医学北京市重点实验室,北京100081

出　　处：《北京大学学报(医学版)》2025年第1期1-6,共6页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金(39270723、30572050、30640093、82270993)。

摘　　要：唾液腺肿瘤是最常见的口腔颌面部肿瘤之一,根据国内7所口腔医学院口腔病理科的统计资料,在69902例口腔颌面部肿瘤中唾液腺上皮性肿瘤有23010例,占32.9%[1]。唾液腺肿瘤的诊断和治疗长期以来一直是北京大学口腔医院的临床特色项目,作者曾于2015年在本刊发表《北京大学口腔医院唾液腺肿瘤研究50年回顾》一文,对2012年前的50年唾液腺肿瘤研究工作做了系统性总结[2],本文介绍近10年本课题组唾液腺肿瘤诊治研究的新进展。Salivary gland tumor is one of the most common tumors in oral and maxillofacial regions.The diagnosis and treatment of salivary gland tumors had been a clinical characteristic project in Peking University School and Hospital of Stomatology since long time ago.Here we introduced the research progress in diagnosis and treatment of salivary gland tumors during the past 10 years.Among 7190 cases of salivary gland tumors treated in this institution,4654 cases(64.7%)were benign,and 2536(35.3%)were malignant,with benign∶malignant ratio of 1.84∶1.Parotid was the most common location,followed by minor salivary gland and submandibular gland,while sublingular gland tumor was seldom seen.The proportion of minor salivary gland tumor was relatively high.Among 1874 cases with primary malignant tumors,the cases with T3 and stageⅢaccounted for only 9.6%and 10.3%,respectively,which indicated that there was shortcoming in the T classification and clinical stage formulated by Union for International Cancer Control(UICC),and further revision was required.The 5,10,and 15 year survival rates of 1637 cases with postoperative follow-up were 93.1%,87.2%and 79.3%,respectively,which were much higher than those we reported 30 years ago.The improvement of treatment results was related to more widely used combined treatment with surgery and postoperative radiotherapy,and the increase in patients with early stage.Adenoid cystic carcinoma was the malignant tumor with high rate of distant metastasis.The 5 and 10 year survival rates of the patients with pulmonary metastasis were 76.2%and 51.8%,respectively,which indicated that the pulmonary metastatic carcinomas developed slowly.Recurrent rate of carcinoma ex pleomorphic adenoma was 46.7%after single treatment of sur-gery,while it decreased to 27.5%after combined theraphy with surgery and radiotherapy,indicating that postoperative radiotheraphy could reduce the recurrent rate effectively.The normal myoepithelial cells had the inhibiting role in the invasion and metastasis of carcinoma ex ple

关 键 词：唾液腺肿瘤 诊断 治疗 发病率 临床病理学 

分 类 号：R739.87[医药卫生—肿瘤]