非痴呆型血管性认知障碍患者血清S100β、IGF-1R水平及意义  

Serum levels and significance of S100βand IGF-1R in vascular cognitive impairment no dementia patients

作　　者：刘珊珊 王丽平[1] 柴娟 LIU Shanshan;WANG Liping;CHAI Juan(Department of Neurology,Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei 430000,China)

机构地区：[1]华中科技大学同济医学院附属梨园医院神经内科,湖北武汉430000

出　　处：《国际检验医学杂志》2025年第3期292-296,共5页International Journal of Laboratory Medicine

基　　金：华中科技大学同济医学院附属梨园医院院内科学研究项目(2023LYYYLCYJ0010)。

摘　　要：目的探讨非痴呆型血管性认知障碍(VCIND)患者血清S100钙结合蛋白β(S100β)、胰岛素样生长因子1受体(IGF-1R)水平及意义。方法选取2022年6月至2023年6月该院收治的因脑梗死引起的VCIND患者50例作为VCIND组,另选取同期该院收治的无认知障碍(NCI)的脑梗死患者50例作为NCI组,以及选取同期该院收治的无脑血管相关病史患者50例作为对照组。采用酶联免疫吸附试验检测血清S100β、IGF-1R水平。采用Logistic回归分析评估血清S100β、IGF-1R水平是否为VCIND的影响因素,并绘制受试者工作特征(ROC)曲线分析血清S100β、IGF-1R水平对VCIND的诊断价值。结果VCIND组、NCI组、对照组高血压占比和Hcy水平比较差异有统计学意义(P<0.05)。VCIND组血清S100β水平高于NCI组、对照组,差异有统计学意义(P<0.05)。VCIND组血清IGF-1R水平低于NCI组、对照组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,血清S100β≥1.26μg/L、IGF-1R≤1.52 ng/mL是VCIND的独立危险因素(P<0.05)。ROC曲线分析结果显示,血清S100β水平对VCIND诊断的曲线下面积(AUC)为0.734(95%CI:0.553~0.769),灵敏度为75.8%,特异度为67.3%,血清IGF-1R水平对VCIND诊断的AUC为0.806(95%CI:0.738~0.932),灵敏度为69.5%,特异度为72.2%。血清S100β、IGF-1R联合检测对VCIND的诊断价值高于单独检测。结论VCIND患者血清S100β水平升高、IGF-1R水平降低,血清S100β、IGF-1R联合检测对VCIND的诊断价值较高,在临床中具有推广应用价值。Objective To investigate the serum levels and significance of S100 calcium-binding proteinβ(S100β)and insulin-like growth factor 1 receptor(IGF-1R)in vascular cognitive impairment no dementia(VCIND)patients.Methods A total of fifty patients with VCIND due to cerebral infarction admitted to a hospital from June 2022 to June 2023 were selected as the VCIND group,50 cerebral infarction patients with no cognitive impairment(NCI)were selected as the NCI group,and 50 patients with no history of cerebrovascular disease admitted to a hospital during the same period were selected as the control group.Serum levels of S100βand IGF-1R were detected by enzyme-linked immunosorbent assay.Logistic regression analysis was used to evaluate whether serum S100βand IGF-1R levels were influential factors in the diagnosis of VCIND,and receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum S100βand IGF-1R level in VCIND.Results There were significant differences in proportion of hypertension and Hcy level among VCIND group,NCI group and control group(P<0.05).The serum S100βlevel in VCIND group was higher than that in NCI group and control group,and the difference was statistically significant(P<0.05).The serum IGF-1R level in VCIND group was lower than that in NCI group and control group,and the difference was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that serum S100β≥1.26μg/L and IGF-1R≤1.52 ng/mL were independent risk factors for VCIND(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum S100βlevel for VCIND diagnosis was 0.734(95%CI:0.553—0.769),sensitivity was 75.8%,specificity was 67.3%,the AUC of serum IGF-1R level for diagnosis of VCIND was 0.806(95%CI:0.738—0.932),sensitivity was 69.5%,specificity was 72.2%.The diagnostic value of serum S100βand IGF-1R combined detection for VCIND was higher than that of single detection.Conclusion Serum S100βlevel increased and IGF-1R level decreased in patients with VCIND

关 键 词：非痴呆型血管性认知障碍 S100钙结合蛋白β 胰岛素样生长因子1受体 

分 类 号：R749.13[医药卫生—神经病学与精神病学]