血清Hcy、HGB及HCT水平与慢性萎缩性胃炎患者病情严重程度及炎性因子水平的相关性研究  

Study on the correlation between serum Hcy,HGB,and HCT levels and the severity of condition and inflammatory factor levels in patients with chronic atrophic gastritis

作　　者：薛梅 贾伟[1] 李旭斌 康春博 孙海英 XUE Mei;JIA Wei;LI Xubin;KANG Chunbo;SUN Haiying(Department of Gastroenterology,Beijing Rehabilitation Hospital Affiliated to Capital Medical University,Beijing 100144,China)

机构地区：[1]首都医科大学附属北京康复医院消化科,北京100144

出　　处：《国际检验医学杂志》2025年第3期319-324,共6页International Journal of Laboratory Medicine

摘　　要：目的探讨血清同型半胱氨酸(Hcy)、血红蛋白(HGB)及红细胞压积(HCT)水平与慢性萎缩性胃炎患者病情严重程度及炎性因子水平的相关性。方法选取2022年1月至2023年12月该院收治的慢性萎缩性胃炎患者122例作为患病组,根据病理分级将患病组分为轻症组(n=63)和重症组(n=59),另选取同期在该院进行体检的健康志愿者106例作为对照组。收集患者临床资料并进行二元Logistic回归分析患者病情严重程度的影响因素,以及采用Pearson相关性分析法分析Hcy、HGB、HCT与炎症因子水平的相关性,绘制受试者工作特征(ROC)曲线分析Hcy、HGB、HCT对患者病情严重程度的诊断价值。结果与对照组比较,患病组血清Hcy水平升高,血清HGB、HCT水平降低,差异有统计学意义(P<0.05)。与轻症组比较,重症组血清Hcy水平升高,HGB、HCT水平降低,差异有统计学意义(P<0.05)。与轻症组比较,重症组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6水平升高,IL-10水平降低,差异有统计学意义(P<0.05)。二元Logistic回归分析结果显示,Hcy、CRP为影响患者病情严重程度的危险因素(P<0.05),HCT、HGB及IL-10为影响患者病情严重程度的保护因素(P<0.05)。Hcy与CRP、TNF-α、IL-6均呈正相关,与IL-10呈负相关(P<0.05)。HGB、HCT与CRP、TNF-α、IL-6呈负相关,与IL-10呈正相关(P<0.05)。ROC曲线分析显示,血清Hcy、HGB、HCT及三者联合诊断患者病情严重程度的曲线下面积分别为0.834、0.814、0.822、0.923,且三者联合诊断价值显著优于Hcy(Z=2.519,P=0.012)、HGB(Z=2.660,P=0.008)、HCT(Z=2.596,P=0.009)单独诊断。结论慢性萎缩性胃炎患者血清Hcy水平升高,血清HGB、HCT水平降低,与患者病情严重程度及炎症因子水平具有相关性,三者联合检测可用于慢性萎缩性胃炎患者病情严重程度的诊断。Objective To investigate the correlation between serum homocysteine(Hcy),hemoglobin(HGB)and hematocrit(HCT)levels and the severity of condition and inflammatory factor levels in patients with chronic atrophic gastritis.Methods A total of 122 patients with chronic atrophic gastritis admitted to a hospital from January 2022 to December 2023 were selected as the disease group,and the disease group was divided into mild group(n=63)and severe group(n=59)according to pathological grades,and 106 healthy volunteers who underwent physical examination in a hospital during the same period were selected as the control group.Clinical data of patients were collected and binary Logistic regression analysis was performed to analyze the factors affecting the severity of patients′condition,and Pearson correlation analysis was used to analyze the correlation between Hcy,HGB,HCT and the levels of inflammatory factors.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of Hcy,HGB and HCT on the severity of patients′condition.Results Compared with the control group,the serum Hcy level in the diseased group was increased,the serum HGB and HCT levels were decreased,the difference was statistically significant(P<0.05).Compared with the mild group,the serum Hcy level in the severe group was increased,the HGB and HCT levels were decreased,and the difference was statistically significant(P<0.05).Compared with mild group,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin(IL)-6 in severe group were increased,and the levels of IL-10 were decreased,with statistical significance(P<0.05).Binary Logistic regression analysis showed that Hcy and CRP were the risk factors affecting the severity of patients′condition(P<0.05),and HCT,HGB and IL-10 were the protective factors affecting the severity of patients′condition(P<0.05).Hcy was positively correlated with CRP,TNF-αand IL-6,and negatively correlated with IL-10(P<0.05).HGB and HCT were negatively correlated with CRP,TNF-�

关 键 词：同型半胱氨酸 血红蛋白 红细胞压积 慢性萎缩性胃炎 

分 类 号：R573.32[医药卫生—消化系统]