Effectiveness of auricular acupoint therapy on chemotherapy‑induced gastrointestinal reaction in breast cancer patients:a systematic review and meta‑analysis  

作　　者：Kangli Chen Ning Zhang Tao Ye 

机构地区：[1]Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou 550025,China [2]Department of Pharmacy,The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou 550001,China [3]Department of Rehabilitation,The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,No.71 North Baoshan Road,Yunyan District,Guiyang,Guizhou 550001,China

出　　处：《Holistic Integrative Oncology》2024年第1期1-16,共16页整合肿瘤学(英文)

基　　金：supported supported by Guiyang Science and Technology Bureau,the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Great Health Science and Technology Cooperation Project(Building Contract[2019]9–2-8);Research Project of Traditional Chinese Medicine and Ethnic Medicine Science and Technology of Guizhou Provincial Administration of Traditional Chinese Medicine(No.QZYY-2019–18);Doctoral Startup Fund of the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine(No.GYZYYFY-BS-2019(03));Doctoral Startup Fund of the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine(No.GYZYYFY-BS-2018(10)).

摘　　要：Objective To evaluate the efficacy of auricular acupoint therapy(AAT)in the treatment of gastrointestinal reactions in patients with breast cancer after chemotherapy.Methods We searched all Randomized controlled trials(RCTs)on AAT for chemotherapy-induced gastrointestinal reaction in breast cancer patients in Pubmed,Embase,and the Cochrane Library in English,and China National Knowledge Infrastructure,WanFang Data,SinoMed and Chongqing VIP in Chinese,from inception to December 31,2023.Meta-analysis was performed using RevMan 5.4 software.Results Twenty RCTs involving 1704 patients were included.All RCTs were reviewed by descriptive analysis,then 19 RCTs were included in the meta-analyses.The results showed:①AAT can improve the symptoms of nausea(OR=3.92,95%CI(1.29,11.93),Z=2.40,P=0.02)and vomiting(OR=2.88,95%CI(1.41,5.88),Z=2.91,P=0.004),not only in acute period[OR=2.83,95%CI(1.73,4.63),Z=4.15,P<0.001],but also in delayed period[OR=5.38,95%CI(3.86,7.50),Z=9.93,P<0.001];AAT can reduce the intensity[WMD=-3.38,95%CI(-5.05,-1.71),P<0.001]and the fre-quency[WMD=-3.29,95%CI(-4.82,-1.76),P<0.001]of nausea both in acute and delayed period;②AAT can reduce the incidence of belching,sour regurgitation,and loss of appetite[OR=0.33,95%CI(0.26,0.41),P<0.001];③AAT can reduce the incidence of constipation[OR=0.17,95%CI(0.08,0.39),Z=4.30,P<0.001],the Constipation assess-ment scale score[WMD=-5.01,95%CI(-6.33,-3.70),P<0.001],the Bristol stool form scale score[WMD=1.01,95%CI(0.68,1.35),P<0.001].④AAT can reduce the Patient assessment of constipation quality of life questionnaire score[WMD=-1.18,95%CI(-1.42,-0.93),P<0.001].Conclusion AAT can alleviate the chemotherapy-induced gastrointestinal reaction in breast cancer patients,includ-ing nausea,vomiting,belching,sour regurgitation,loss of appetite and constipation,improve quality of life.

关 键 词：Auricular acupoint therapy Breast cancer CHEMOTHERAPY Gastrointestinal reaction META-ANALYSIS 

分 类 号：R73[医药卫生—肿瘤]