Use of 125 iodine seeds for intra‑operative localization of nonpalpable breast lesions(ROLLIS):analysis of the implant of 1757 seeds in 1477 patients  

作　　者：Antônio Campbell Penna Carlos Antônio da Silva Franca Maria Veronica Fonseca Torres de Oliveira Lea Mirian Barbosa da Fonseca Paula de Azevedo Brant Saldanha Jacir Luiz Balen Augusto Cesar Peixoto Rocha Fernanda Philadelpho Arantes Pereira Valeska Caldoncelli Andrade Rafael Henrique Szymanski Machado Maria Julia Gregório Calas Mauricio A.M.Costa 

机构地区：[1]Instituto Brasileiro de Oncologia,Rio de Janeiro,RJ,Brazil [2]LBG Celular Diagnóstico,Rio de Janeiro,RJ,Brazil [3]Universidade Federal do Rio de Janeiro(UFRJ),Rio de Janeiro,RJ,Brazil [4]Centro de Oncologia Integrado,Rio de Janeiro,RJ,Brazil [5]Hospital Universitário Clementino Fraga Filho,UFRJ,Rio de Janeiro,RJ,Brazil [6]Clínica de Diagnóstico por Imagem,Rio de Janeiro,RJ,Brazil [7]Centro de Ensino e Pesquisa da Mulher,Rio de Janeiro,RJ,Brazil [8]Hospital Federal da Lagoa,Rio de Janeiro,RJ,Brazil [9]Rede D′Or Sao Luiz,Rio de Janeiro,RJ,Brazil [10]Academia Nacional de Medicina,Rio de Janeiro,RJ,Brazil [11]National Academy of Medicine,Holistic Integrative Oncology Journal,Rua Sorocaba 464/202,Botafogo,Rio de Janeiro 22271-110,Brazil

出　　处：《Holistic Integrative Oncology》2024年第1期394-400,共7页整合肿瘤学(英文)

摘　　要：Objective To analyze the feasibility,efficacy and results of the use of 125Iodine seeds for intra-operative localization of nonpalpable breast lesions.Method Retrospective review of 1477 patients referred by various breast specialist surgeons,with radiologically detected but clinically nonpalpable microcalcifications,asymmetric density or nodules,submitted to pre-operatory 125Iodine seed implant,between July 2012 and September 2023.A total of 1757 seeds were implanted in ordinary radiologic departments,supported by ultrasonography or mammography exams,chosen according to the morpho-logic aspect of the lesion.Radioguided surgical procedure took place on the same day or few days after the implant of the seeds,with the help of a radiation detector called Gamaprobe,which directs the surgeons towards the radioac-tive seeds and to the lesion to be resected.Results All implants were performed as outpatient procedures,with patients immediately returning to their daily activities.No complications such as pain,bleeding,infection,and hematoma were recorded.Pathologists had no dif-ficulty in preparing the surgical specimens for histopathologic analysis.Surgical safety margins were considered adequate in all pathologic reports,with no need for re-operations.The healing process was not jeopardized by radia-tion,and the surgeons were pleased with the improvement in intraoperative lesion localizations and the shortening on operatory time.Cosmetic results were well accepted by the patients.Conclusion The 125Iodine seed implant is an effective alternative method for intraoperative localization of radiologi-cally detectable and clinically nonpalpable breast lesions.

关 键 词：Breast Iodine radioisotopes Breast diseases Diagnostic techniques RADIOISOTOPE 

分 类 号：R73[医药卫生—肿瘤]