Investigation of clinicopathological characteristics and prognosis of abdominal Desmoid tumors  

作　　者：Yujuan Jiang Xinxin Shao Weikun Li Haitao Hu Yiming Lu Yantao Tian 

机构地区：[1]Department of Pancreatic and Gastric Surgery,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,No.17 Panjiayuan Nanli,Chaoyang District,Beijing 100021,China

出　　处：《Holistic Integrative Oncology》2024年第1期510-516,共7页整合肿瘤学(英文)

基　　金：supported by the National Natural Science Foundation of China(82072734).

摘　　要：Background Abdominal desmoid tumors(DTs)are rare soft-tissue neoplasms known for their relatively high local recurrence rate.This study aims to elucidate the clinicopathological features and investigate prognostic factors related to abdominal DTs across various tumor locations.Methods From January 2000 to January 2021,patients diagnosed with abdominal DTs who underwent complete resection at the Cancer Hospital,Chinese Academy of Medical Sciences,were included in this study.Thorough collec-tion and review of clinicopathologic characteristics and follow-up data were performed.Prognostic factors,includ-ing age at presentation,sex,tumor location,size,and proximity to nerves or vasculature,were meticulously analyzed to assess their impact on recurrence-free survival.Results A cohort of 226 patients diagnosed with abdominal DTs was categorized into two groups based on tumor site:the abdominal wall group(n=132)and the intra-abdominal cavity group(n=94).Distinct clinicopathological features and prognoses were observed between abdominal wall DTs and intra-abdominal DTs.During a median fol-low-up of 60 months,24 patients(10.2%)experienced local recurrence.Univariate and multivariate analyses identified intra-abdominal tumors,tumor size>10cm,and positive margins as independent risk factors associated with poor prognosis.Conclusion Abdominal wall DTs demonstrate different clinicopathological characteristics and better prognoses compared to intra-abdominal DTs.By achieving negative margins,patients with abdominal wall DTs can achieve favorable therapeutic outcomes and prognosis through curative resection.

关 键 词：Desmoid tumor ABDOMEN Surgical resection RECURRENCE PROGNOSIS 

分 类 号：R73[医药卫生—肿瘤]