Phagocytosis:strategies for macrophages to hunt Mycobacterium tuberculosis  

作　　者：Donghui Liu Jiangmei Wang Zhengzhong Xu Xiang Chen Xin’an Jiao 

机构地区：[1]Jiangsu Key Laboratory of Zoonosis/Jiangsu Co‑Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou University,Yangzhou 225009,China [2]Key Laboratory of Prevention and Control of Biological Hazard Factors(Animal Origin)for Agrifood Safety and Quality of Ministry of Agriculture and Rural Affairs,Yangzhou University,Yangzhou 225009,China

出　　处：《One Health Advances》2024年第1期10-19,共10页全健康进展(英文)

基　　金：supported by grants from the National Key Research and Development Program of China(grant 2021YFD1800403);the Jiangsu Agricultural Science and Technology Independent Innovation Funds(CX(21)1004);the Science and Technology Program of Jiangsu(BE2021331);the 111 Project(D18007),the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).

摘　　要：Macrophages,as crucial innate immune cells,play a fundamental role in combating Mycobacterium tuberculosis(Mtb).The most powerful strategy for macrophages to eliminate Mtb is phagocytosis.They identify extracellular pathogens through various receptors and then engulf them,eliminating pathogenic microorganisms through reactive oxygen species,reactive nitrogen species,and a range of enzymes derived from phagosome-lysosome fusion.However,this process may also provide a potential ecological niche for Mtb.This is due to the fact that Mtb is capable of ensuring its survival within macrophages.Mtb infection results in obstructing the usual phagosome maturation and acidi-fication.In addition,Mtb is capable of escaping from phagosomes and entering the cytoplasm of its host cell.This process of escaping phagosomes appears to promote necrosis in infected macrophages,and facilitate the expansion of intracellular bacterial populations.Therefore,enhancing the bactericidal capacity of macrophages or preventing Mtb invasion may prove to be a promising strategy for the adjuvant treatment of tuberculosis.This review highlights the processes and outcomes of macrophage recognition and phagocytosis of Mtb,and describes the mechanisms involved in Mtb resistance to phagocytosis.Moreover,recent advances in the modulation of macrophage phagocyto-sis to assist in the treatment of tuberculosis will be discussed.

关 键 词：PHAGOCYTOSIS MACROPHAGES Mycobacterium tuberculosis 

分 类 号：R52[医药卫生—内科学]