Seven-year overview of antimicrobial resistance in diarrheagenic Escherichia coli from sporadic human diarrhea cases in 20 Chinese provinces  

作　　者：Haihong Han Weiwei Li Jikai Liu Xiaoai Zhang Xiang Huo Yong Sun Jiancai Chen Ruyue Fan Jing Zhang Yong Chen Hongxia Yang Shuai Chen Yanfen Li Dongmei Tan Xuemin Ma Penghui Fan Shaofei Yan Yunchang Guo 

机构地区：[1]NHC Key Laboratory of Food Safety Risk Assessment,Food Safety Research Unit(2019RU014)of Chinese Academy of Medical Science,China National Center for Food Safety Risk Assessment,Beijing 100022,China [2]Beijing Center for Disease Control and Prevention,Beijing 100013,China [3]Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China [4]Anhui Provincial Center for Disease Control and Prevention,Hefei 230601,China [5]Zhejiang Provincial Center for Disease Prevention and Control,Hangzhou 310051,China [6]Shandong Provincial Center for Disease Prevention and Control,Jinan 250014,China [7]Gansu Provincial Center for Disease Prevention and Control,Lanzhou 730000,China [8]Shanghai Center for Disease Prevention and Control,Shanghai 200336,China [9]Shanxi Provincial Center for Disease Prevention and Control,Taiyuan 030012,China [10]Hunan Provincial Center for Disease Control and Prevention,Changsha 410005,China [11]Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016,China [12]Guangxi Center for Disease Prevention and Control,Nanning 530028,China [13]Ningxia Center for Disease Prevention and Control,Yinchuan 750004,China

出　　处：《One Health Advances》2024年第1期42-50,共9页全健康进展(英文)

基　　金：support provided by The National Key Research and Development Program of China,under Grant number 2022YFD1800403.

摘　　要：Diarrheagenic Escherichia coli is one of the most prevalent foodborne pathogens and poses significant clinical chal-lenges due to increasing rates of antibiotic resistance.In this study,9,068 diarrheagenic E.coli isolates from sporadic diarrhea cases across 20 provinces of China from 2016 to 2022 were systematically analyzed to determine the preva-lence and distribution of resistance.A total of 14 antibiotics were included in the antimicrobial resistance surveil-lance.Antimicrobial susceptibility testing indicated that the majority of the isolates(89.3%)were resistant to at least one antimicrobial agent,with a significant proportion(60.3%)demonstrating multidrug resistance.Isolates showed high levels of resistance to ampicillin(68.2%)and high sensitivity to imipenem(97.0%).Over the 7 years,an increas-ing trend in resistance to cefoxitin and chloramphenicol among the isolates was found.Enteroaggregative E.coli was identified as the predominant pathotype.Furthermore,antimicrobial resistance rates were higher among the iso-lates from infants under 1 year of age compared to other populations and resistance levels differed among patho-types.In summary,our findings revealed the detailed resistance characteristics of diarrheagenic E.coli strains isolated from human sporadic diarrhea cases in China,offering valuable insights that can inform clinical antibiotic treatment strategies and priorities.

关 键 词：Foodborne disease Diarrheagenic Escherichia coli Antimicrobial resistance 

分 类 号：R57[医药卫生—消化系统]