Advances in porcine respiratory and intestinal organoids:status and potential application for virus infections  

作　　者：Chunru Liu Xiaoqing Dong Pinghuang Liu Xi Lin 

机构地区：[1]National Key Laboratory of Veterinary Public Health and Safety,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China [2]Laboratory of Developmental Nutrition,Department of Animal Sciences,North Carolina State University,Raleigh,NC 27695,USA

出　　处：《One Health Advances》2024年第1期111-121,共11页全健康进展(英文)

基　　金：supported by the grant from the Chinese Universities Scientific Fund(2023RC046)and North Carolina Agricultural Research Services.

摘　　要：The respiratory tract and digestive tract serve as the gateway between the host and the environment,play-ing an important role in protecting against viral infections.Diseases caused by viruses that infiltrate the respira-tory and gastrointestinal tracts account for the major infectious diseases in pigs,resulting in significant economic losses for the swine industry.However,studies on virus-host interactions are limited due to the lack of suitable research models that can effectively stimulate the highly complex physiological characteristics found in vivo.With the advancement in stem cell technology,organoids that more closely recapitulate the structure,function,and organ-ization of specific organs or tissues in vitro have gradually become a research hotspot.These novel ex vivo models are critical for studying viral infection,investigating viral pathogenesis,elucidating virus-host interactions and devel-oping preventive and therapeutic approaches.Currently,respiratory organoids and intestinal organoids(IOs)have been widely applied in the study of infectious diseases.Therefore,this review primarily summarizes the development of porcine respiratory and intestinal organoids,their applications in studying infection,current limitations,and future perspectives.

关 键 词：Respiratory tract INTESTINE Organoid Virus Pig 

分 类 号：R57[医药卫生—消化系统]