Changing antimicrobial resistance profile of Enterobacter spp.isolates in hospitals across China:a seven-year analysis from the CHINET antimicrobial resistance surveillance program(2015-2021)  

作　　者：Shaozhen Yan Ziyong Sun Yang Yang Demei Zhu Zhongju Chen on behalf of the China Antimicrobial Surveillance Network(CHINET)Study Group 

机构地区：[1]Department of Laboratory Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Institute of Antibiotics,Huashan Hospital,Fudan University,Shanghai 200040,China [3]不详

出　　处：《One Health Advances》2024年第1期243-249,共7页全健康进展(英文)

摘　　要：Antimicrobial resistance poses a global threat to human health.Analyzing monitoring data on antimicrobial resist-ance can assist clinicians in making strategic decisions and promptly identifying outbreaks of antimicrobial-resistant organisms.The China Antimicrobial Surveillance Network(CHINET)was established in 2004 to monitor the trends in bacterial epidemiology and antimicrobial resistance.In this study,we analyzed the distribution and changing anti-microbial resistance profiles of Enterobacter spp.isolated from 53 hospitals across China between 2015 and 2021 using the CHINET data.Over the seven-year period,a total of 37,966 clinical isolates of Enterobacter spp.were obtained,accounted for 2.5%of all isolates and 5.7%of Enterobacteriaceae isolates.Among those isolates,Enterobacter cloacae was the most prevalent,comprising 93.7%(35,571/37,966).The majority of strains were isolated from respiratory tract samples(44.6%),followed by secretion,pus(16.4%),and urine samples(16.0%).As for patient composition,37,966 Enterobacter spp.strains were predominantly isolated from inpatients(92.9%),whereas 7.1%were isolated from out-patients and emergency patients.Among inpatients,isolates from patients in surgical ward accounted for the highest percentage(24.4%).E.cloacae exhibited the lowest rates of resistance to amikacin,tigecycline,polymyxin B,imipe-nem,and meropenem(resistance rates<8%).However,the percentage of carbapenem-resistant Enterobacter spp.was 10.0%,presenting a rising tendency over the 7-year study period.Antimicrobial resistance profiles of Enterobacter spp.isolates varied according to the department of isolation and patient age(adult or child),with the intensive care unit having the highest proportion of carbapenem-resistant Enterobacter spp.isolates.

关 键 词：ENTEROBACTER Enterobacter cloacae Antimicrobial resistance surveillance Carbapenem resistance 

分 类 号：G63[文化科学—教育学]