基因编辑在肝胆外科中的应用  

Application of Gene Editing in Hepatobiliary Surgery

作　　者：王虓 沈银峰[2,3] WANG Xiao;SHEN Yinfeng(The First Clinical Medical College,Hubei University of Chinese Medicine,Wuhan 430065,Hubei,China;Department of Hepatobiliary Surgery,Hubei Provincial Hospital of Traditional Chinese Medicine,Affiliatedwith Hubei University of Traditional Chinese Medicine,Wuhan 430061,Hubei,China;Hubei Shizhen Laboratory,Wuhan 430065,Hubei,China)

机构地区：[1]湖北中医药大学第一临床学院,湖北武汉430065 [2]湖北中医药大学附属湖北省中医院肝胆外科,湖北武汉430061 [3]湖北时珍实验室,湖北武汉430065

出　　处：《医学信息》2025年第1期168-173,184,共7页Journal of Medical Information

基　　金：湖北省中医药管理局2023-2024年度中医药重点项目(编号:ZY2023Z001);湖北省时珍人才工程项目(编号:鄂卫医〔2024〕256号)。

摘　　要：肝胆疾病种类繁多,其中有不少常规治疗效果有限的危重疾病,尤其是涉及代谢、消耗等问题的疾病需要新的治疗手段。CRISPR/Cas9是目前常见的基因编辑技术之一,具有原理简单,操作方便灵活等优点,可满足肝胆疾病的基因研究需求。近年来,已有不少使用CRISPR/Cas9研究治疗肝胆疾病的成果出现,甚至不乏疑难杂症的相关研究。本综述通过回顾近10年相关研究,从多个肝胆外科疾病角度逐一叙述并分析基因编辑技术的优势与潜力,为将来实现基因编辑技术大规模应用于临床提供参考。There are various types of hepatobiliary diseases,among which many critical diseases getting limited therapeutic effects after routine treatment need new treatment methods,especially for those involving metabolism,consumption,and other issues.As a common gene editing techniques,CRISPR/Cas9 has the advantages of simple principle,convenient and flexible operation,which can satisfy the genetic research requirements of hepatobiliary diseases.In recent years,many research results using CRISPR/Cas9 to study the treatment of hepatobiliary diseases have emerged,many of which related to difficult and complex diseases.By reviewing relevant research in the past 10 years,the advantages and potential of gene editing technology are described and analyzed from the perspectives of multiple liver and gallbladder surgical diseases in this review,so as to provide reference for the realization of applying gene editing on a large scale in clinical practice in the future.

关 键 词：基因编辑 肝病 胆道疾病 肝移植 

分 类 号：R575[医药卫生—消化系统]