食用菌麦角硫因的研究进展  

Recent progress in ergothioneine of edible fungi

作　　者：杨林雷 沈真辉 罗祥英 李荣平[1] 李荣春 YANG Linlei;SHEN Zhenhui;LUO Xiangying;LI Rongping;LI Rongchun(Kunming(Edible Fungi)Enterprise Technology Center,Yunnan(Rare Edible Fungi)Enterprise Technology Center,Yunnan Junshijie Biotechnology Co.Ltd.,Kunming 650200,Yunnan,China;Zhang Jinsong Expert Workstation of Yunnan Province,Kunming 650200,Yunnan,China;Zhang Jinsong Medicinal Fungi Expert Workstation of Yunnan(Kunming),Kunming 650200,Yunnan,China;Institute of Edible Fungi,Yunnan Agricultural University,Kunming 650201,Yunnan,China)

机构地区：[1]云南菌视界生物科技有限公司云南省级(珍稀食用菌)企业工程技术中心昆明市级(食用菌)企业工程技术中心,云南昆明650200 [2]云南省张劲松专家工作站,云南昆明650200 [3]云南(昆明)张劲松药用真菌专家工作站,云南昆明650200 [4]云南农业大学食用菌研究所,云南昆明650201

出　　处：《生物工程学报》2025年第2期574-587,共14页Chinese Journal of Biotechnology

基　　金：云南省张劲松专家工作站(202305AF150084);云南(昆明)张劲松药用真菌专家工作站(YSZJGZZ-2022043)。

摘　　要：麦角硫因是具有较强抗氧化和抗炎作用的天然抗氧化剂,已在食品、化妆品、药品等领域广泛应用,食用菌(含野生和栽培)是最大宗的能够天然合成麦角硫因的生物。本文综述了近年来食用菌中麦角硫因的含量、生理功能、提取检测、合成基因及途径、通过菌丝体发酵和工程菌构建生产麦角硫因等方面的研究进展,为食用菌麦角硫因的研究和开发提供了参考。Ergothioneine is a natural antioxidant known for its potent anti-inflammatory and antioxidative properties.It has been applied in various sectors such as food,cosmetics,and pharmaceuticals.Edible fungi,both wild and cultivated,stand as the primary natural sources capable of synthesizing ergothioneine.This paper reviews the research progress in the content,physiological functions,extraction and detection methods,synthetic genes and pathways,mycelium fermentation,and engineering strain construction for ergothioneine production.The aim is to provide a comprehensive reference for advancing the research and industrial development related to ergothioneine in edible fungi.

关 键 词：食用菌 麦角硫因 提取检测 合成基因 工程菌株 

分 类 号：S646[农业科学—蔬菜学]