Current status and new directions for hepatocellular carcinoma diagnosis  

作　　者：Jinqi Tu Bo Wang Xiaoming Wang Kugeng Huo Wanting Hu Rongli Zhang Jinyao Li Shijie Zhu Qionglin Liang Shuxin Han 

机构地区：[1]Xinjiang Key Laboratory of Biological Resources and Genetic Engineering,College of Life Science and Technology,Xinjiang University,Urumqi,Xinjiang,China [2]Department of Hepatobiliary Surgery,The First Affiliated Hospital of Wannan Medical College(Yijishan Hospital of Wannan Medical College),Wuhu,Anhui,China [3]Animal Experimental Center,Xinjiang Medical University,Urumqi,Xinjiang,China [4]Cyagen Biosciences(Guangzhou)Inc.,Guangzhou,Guangdong,China [5]MOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology,Beijing Key Lab of Microanalytical Methods&Instrumentation,Center for Synthetic and Systems Biology,Department of Chemistry,Tsinghua University,Beijing,China [6]Department of Medicine,Institute for Transformative Molecular Medicine,Case Western Reserve University School of Medicine,Cleveland,OH,USA [7]Cardiovascular Research Institute,Case Western Reserve University School of Medicine,Cleveland,OH,USA [8]Department of Oncology,Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing,China

出　　处：《Liver Research》2024年第4期218-236,共19页肝脏研究(英文)

基　　金：supported by the National Natural Science Foundation of China(No.32171167);Anhui Province Educational Natural Science Project(No.2023AH040254);Tianchi Talent Introduction Plan Innovative Leader of Xinjiang Ugyur Autonomous Region(No.51052401403).

摘　　要：Liver cancer ranks as the sixth most common cancer globally,with hepatocellular carcinoma(HCC)accounting for approximately 75%-85%of cases.Most patients present with moderately advanced disease,while those with advanced HCC face limited and ineffective treatment options.Despite diagnostic efforts,no ideal tumor marker exists to date,highlighting the urgent clinical need for improved early detection of HCC.A key research objective is the development of assays that target specific pathways involved in HCC progression.This review explores the pathological origin and development of HCC,providing insights into the mechanistic rationale,clinical statistics,and the advantages and limitations of commonly used diagnostic tumor markers.Additionally,it discusses the potential of emerging biomarkers for early diagnosis and offers a brief overview of relevant assay methodologies.This review aims to summarize existing markers and investigate new ones,providing a basis for subsequent research.

关 键 词：Hepatocellular carcinoma(HCC) Tumor marker Early detection Pathological origin and development 

分 类 号：R73[医药卫生—肿瘤]