Cigarette smoking and alcohol-related liver disease  

作　　者：Hui-Min Lin Jing-Rong Zhang Meng-Xue Li Hui Hou Hua Wang Yan Huang 

机构地区：[1]Anhui Provincial Laboratory of Inflammatory and Immunity Disease,Anhui Institute of Innovative Drugs,School of Pharmacy,Anhui Medical University,Hefei,Anhui,China [2]Department of Pharmacy,The Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui,China

出　　处：《Liver Research》2024年第4期237-245,共9页肝脏研究(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(82370591);Hefei Natural Science Foundation of China(2023018);Scientific Research Project of Colleges and Universities of Anhui Province(Natural Science)(2023AH040078);Anhui Medical University Research Level Improvement Program(2023xkjT010).

摘　　要：China is a major consumer of alcohol and tobacco.Tobacco and alcohol use are closely linked,with up to 90%of alcoholics having a history of tobacco use,and heavy smokers also tending to be alcoholics.Alcohol-related liver disease(ALD),one of the most common and serious complications of chronic alcohol intake,involving hepatic steatosis,hepatitis,hepatic fibrosis,cirrhosis and hepatocellular carcinoma(HCC),has become one of the globally prevalent chronic diseases.An increasing number of studies have focused on the association between smoking and ALD and explored the mechanisms involved.Clinical evidence suggests that smoking has a negative impact on the incidence and severity of fatty liver disease,progression of liver fibrosis,development of HCC,prognosis of patients with advanced liver disease,and alcohol-related liver transplant recipients.The underlying mechanisms are complex and involve different pathophysiological pathways,including free radical exposure,endoplasmic reticulum stress,insulin resistance,and oncogenic signaling.This review discusses the deleterious effects of smoking on ALD patients and the possible underlying mechanisms at several levels.It emphasizes the importance of discouraging smoking among ALD patients.Finally,the pathogenic role of electronic cigarettes,which have emerged in recent years,is discussed,calling for an emphasis on social missions for young people.

关 键 词：Cigarette smoking(CS) Alcohol-related liver disease(ALD) Electronic cigarettes(E-cigarettes) ALCOHOLISM Liver transplantation(LT) 

分 类 号：R57[医药卫生—消化系统]