Polyphenol-based photothermal nanoparticles with sprayable capability for self-regulation of microenvironment to accelerate diabetic wound healing  

作　　者：Xiuhong Huang Meimei Fu Min Lu Xiaoxian Wu Weiqian David Hong Xiaoying Wang Panpan Wu Keke Wu 

机构地区：[1]School of Biomedical Engineering,Affiliated Cancer Hospital&Institute,Guangzhou Medical University,Guangzhou 511495,PR China [2]School of Biotechnology and Health Sciences,Wuyi University,Jiangmen 529020,PR China [3]Department of Histology and Embryology,School of Basic Medical Sciences,Southern Medical University,Guangzhou 510515,PR China [4]Instrumental Analysis and Research Centre,South China Agricultural University,Guangzhou 510642,PR China [5]Stomatological Hospital,School of Stomatology,Southern Medical University,Guangzhou 510280,PR China [6]Department of Chemistry,University of Liverpool,Liverpool L697ZD,UK

出　　处：《Engineered Regeneration》2024年第4期505-520,共16页再生工程(英文)

基　　金：supported by the National Natural Science Foundation of China(No.32201077);Guangdong Basic and Applied Basic Research Foundation(No.2022A1515011982);Foundation of the Department of Education of Guangdong Province(No.2022KTSCX144),Basic Research Program of Guangzhou Science and Technology Bu;reau(G24151031);Guangdong Province University Characteristic Innovation Project(06-410-1013);Chinese Post-doctoral Science Foundation(2023M740847);the Project of the State Key Laboratory of Respiratory Disease(SKLRD-Z-202105);Science and Technology Innovation Project of Foshan City(1920001000025).

摘　　要：Current treatments for diabetic wounds have some curative effect,but the process is complicated and lack user-friendly wound dressings.Nanozymes have gained significant attention for wound healing due to their strik-ing merits.Herein,we have developed a novel sprayable tannin acid-cobalt coordination nanozyme(TACo)for diabetic wound healing.TACo nanozyme offers a convenient and efficient methods by spraying directly onto wounds surface,reducing infection risk by avoiding direct contact.Notably,its antioxidant properties contribute to scavenging the reactive oxygen species(ROS),alleviating oxidative stress and inflammation of wound mi-croenvironment.Additionally,TACo nanozyme could promote cell survival and multiplication,which is crucial for the wound healing process.Importantly,TACo nanozyme facilitates angiogenesis by enhancing cell viability,migration,and tube formation.The unique coordination between metal and phenolic components confers pH-responsive cobalt ion and TA release properties,avoiding secondary damage during the wound cleaning.This unique composition seamlessly integrates photothermal antibacterial therapy,inflammatory microenvironment management,supporting for angiogenesis,and effective promotion of extracellular matrix production sequen-tially by harnessing the acidic pH environment of diabetic wounds.In conclusion,the development of a sprayable TACo nanozyme presents a promising therapeutic approach for the treatment of diabetic wounds,addressing the complexities of current treatments and providing a user-friendly application method.

关 键 词：Nanozyme Sprayable POLYPHENOL Cobalt ion Diabetic wound 

分 类 号：R58[医药卫生—内分泌]