Animal modeling for myopia  

作　　者：Lingman Zheng Zhiyong Liao Jian Zou 

机构地区：[1]Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection,College of Life and Environmental Science,Wenzhou University,Wenzhou,China [2]Eye Center of the Second Affiliated Hospital,Center for Genetic Medicine,Zhejiang University International Institute of Medicine,Zhejiang University School of Medicine,Hangzhou,China

出　　处：《Advances in Ophthalmology Practice and Research》2024年第4期173-181,共9页眼科实践与研究新进展(英文)

基　　金：sponsored by the National Natural Science Foundation of China(NSFC)Projects 82371870 to JZ.

摘　　要：Background:Myopia is one of the most common eye diseases globally,and has become an increasingly serious health concern among adolescents.Understanding the factors contributing to the onset of myopia and the strategies to slow its progression is critical to reducing its prevalence.Main text:Animal models are key to understanding of the etiology of human diseases.Various experimental animal models have been developed to mimic human myopia,including chickens,rhesus monkeys,marmosets,mice,tree shrews,guinea pigs and zebrafish.Studies using these animal models have provided evidences and perspectives on the regulation of eye growth and refractive development.This review summarizes the characteristics of these models,the induction methods,common indicators of myopia in animal models,and recent findings on the pathogenic mechanism of myopia.Conclusions:Investigations using experimental animal models have provided valuable information and insights into the pathogenic mechanisms of human myopia and its treatment strategies.

关 键 词：MYOPIA Experimental myopia animal models Form-deprivated myopia Lens-induced myopia Eye growth Refractive development Corneal remodeling 

分 类 号：R73[医药卫生—肿瘤]