Therapeutic effectiveness of different machines in intense pulsed light treatment of meibomian gland dysfunction  

作　　者：Zhenwei Qin Yirui Zhu Jiale Lu Lin Lin Yanan Huo Haoyu Wang Chen Qiao Xiangxi Chen Jianhua Wu Qingyan Zeng Xiuming Jin 

机构地区：[1]Eye Center of the 2nd Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang Provincial Key Lab of Ophthalmology,Hangzhou,China [2]Wuhan Aier Eye Hospital,Wuhan,China [3]Hankou Aier Eye Hospital,Wuhan,China

出　　处：《Advances in Ophthalmology Practice and Research》2024年第4期182-188,共7页眼科实践与研究新进展(英文)

基　　金：supported by the National Natural Science Foundation of China:[grant numbers:82171013,81870624];Major Science and Technology Projects of Zhejiang Province[grant numbers:2022C03173].

摘　　要：Purpose:This study aimed to determine the therapeutic effectiveness of different machines in intense pulsed light(IPL)treatment of meibomian gland dysfunction(MGD).Methods:213 subjects diagnosed with MGD underwent three sessions of IPL treatment in a control(M22)treatment group or experimental(OPL-I)treatment group and were followed up three to four weeks after each session.Tear breakup time(TBUT),meibomian gland secretion scores(MGSS),meibomian gland meibum scores(MGMS),corneal fluorescein staining(CFS)scores,and the Standard Patient Evaluation of Eye Dryness(SPEED)was used to assess eye dryness signs and symptoms at baseline and follow-up visits.Results:Two machines had the same working principles except that experimental(OPL-I)group consist of a dual filter system.Both groups showed significant improvements(P<0.0001)in TBUT,MGSS,MGMS,CFS scores and SPEED scores.Non-inferiority analysis showed no statistically significant differences in any result between the two groups.Various defects appeared on the filter with the extension of usage time.Spectrophotometry showed that light intensity decreased to 93.5%±0.46%past the first filter.Conclusions:IPL treatment completed with different machines have the same effect on improving the symptoms and signs of MGD.The dual filter system in the IPL machine reduces light intensity by approximately 6.5%without affecting its therapeutic effect.It is a feasible measure to ensure double safety and has the significance of popularization not only for MGD but also in other IPL treatment scenarios.

关 键 词：MGD IPL Non-inferiority analysis Dual filter system 

分 类 号：R57[医药卫生—消化系统]