ABC转运蛋白与癌症多药耐药性  

ABC transporters and multidrug resistance in cancer

作　　者：张博涵 薄乐涛 朱潇昀 陈曙贞 韦柳娅 陈哲生[1] ZHANG Bohan;BO Letao;ZHU Xiaoyun;CHEN Shuzhen;WEI Liuya;CHEN Zhesheng(Department of Pharmaceutical Sciences,College of Pharmacy and Health Sciences,St.John's University,New York 11439,USA;Faculty of Science,the University of Hong Kong,China;School of Pharmacy,Shandong Second Medical University School of Pharmaceutical Sciences)

机构地区：[1]圣约翰大学药学与健康科学学院药学系,皇后区美国纽约11439 [2]香港大学理学院,中国香港 [3]山东第二医科大学药学院

出　　处：《山东第二医科大学学报》2024年第5期321-354,共34页Journal of Shandong Second Medical University

摘　　要：ABC转运蛋白家族在癌症耐药性中具有重要作用,包含7个亚家族(ABCA、ABCB、ABCC、ABCD、ABCE、ABCF和ABCG),每个亚家族各具不同的结构和功能。这些转运蛋白通过移除细胞内的化疗药物或其他有害物质,降低药效,从而导致多药耐药(MDR)现象。其中,ABCB1(P-gp)和ABCG2(BCRP)是被研究最多的成员,其过表达与多种癌症的耐药性密切相关。研究显示,ABCB家族能有效排除如紫杉醇、阿霉素和长春新碱等抗癌药物,而ABCC家族也与多药耐药有显著相关性。ABCD家族在多种癌症中也展现出潜在的耐药机制。尽管已有多种抑制剂针对这些转运蛋白以恢复化疗效用,但临床应用仍面临挑战。深入理解ABC转运蛋白在癌症发展中的复杂角色,将为未来设计新型抗癌策略提供重要思路。对全家族成员的功能特征及相互作用的系统研究,将有助于找到有效的治疗方法以克服癌症耐药性。The ABC transporter family plays a crucial role in cancer drug resistance,comprising seven subfamilies(ABCA,ABCB,ABCC,ABCD,ABCE,ABCF,and ABCG),each with distinct structural and functional characteristics.These transporters reduce the efficacy of chemotherapy drugs by removing them or other harmful substances from cells,leading to multidrug resistance(MDR).Among them,ABCB1(P-gp)and ABCG2(BCRP)are the most studied,with their overexpression closely linked to resistance in various cancers.Research indicates that the ABCB family effectively expels anticancer drugs like paclitaxel,doxorubicin,and vincristine,while the ABCC family is also significantly associated with MDR.The ABCD family shows potential resistance mechanisms in several cancer types.Although various inhibitors have been developed to target these transporters and restore chemotherapy effectiveness,clinical application remains challenging.A deeper understanding of the complex roles of ABC transporters in cancer progression will provide valuable insights for designing novel anticancer strategies.Systematic studies of the functional characteristics and interactions of all family members will aid in finding effective treatments to overcome cancer drug resistance.

关 键 词：ABC转运蛋白 多药耐药性 长春新碱 ABCG2 化疗药物 抗癌药物 耐药机制 癌症 

分 类 号：R730.5[医药卫生—肿瘤]