25-羟基维生素D的血清水平与特发性良性阵发性位置性眩晕的关系  

Serum levels of 25-hydroxy vitamin D correlate with idiopathic benign paroxysmal positional vertigo

作　　者：肖萌 李银柱 于倩倩 丁静 XIAO Meng;LI Yinzhu;YU Qianqian;DING Jing(Department of Nenrology,Sunshine Union Hospital,Weifang 261100,China;Department of Gastroenterology,Gaoxin District Weifang People Hospital)

机构地区：[1]山东阳光融和医院神经内科,山东潍坊261100 [2]潍坊市高新技术产业开发区人民医院消化内科

出　　处：《山东第二医科大学学报》2024年第5期396-400,共5页Journal of Shandong Second Medical University

基　　金：潍坊市科技发展计划项目(项目编号:2022YX115)。

摘　　要：目的探讨特发性良性阵发性位置性眩晕(BPPV)的发生和复发与血清25-羟基维生素D[25(OH)D]水平的关系。方法选择2022年1月1日~2024年5月31日连续入组的特发性BPPV患者174例为病例组,同时纳入348例性别、年龄与病例组匹配的健康者为对照组。用二元Logistic回归分析25(OH)D水平对BPPV发生和复发的影响。结果病例组108例有维生素D缺乏症,患病率为62.1%,高于对照组(42.8%),血清25(OH)D水平明显低于对照组,差异有统计学意义(P<0.001)。病例组中特发性BPPV复发组血清25(OH)D水平明显低于未复发组(11.2μg/L vs 18.7μg/L),差异有统计学意义(P<0.001)。回归分析显示维生素D缺乏与BPPV发生和复发相关,OR值分别为2.15(95%CI 1.30-4.32;P=0.006)和5.16(95%CI 1.00-34.12;P=0.05)。结论血清25(OH)D水平降低与BPPV的发生和复发相关。Objective To investigate the relationship between the incidence and recurrence of idiopathic benign paroxysmal positional vertigo(BPPV)and the level of serum 25-hydroxyvitamin D[25(OH)D].Methods A total of 174 consecutive idiopathic BPPV patients enrolled from January 1,2022 to May 31,2024 were selected as the case group.Meanwhile,348 healthy individuals matched with the case group in terms of gender and age were included as the control group.Binary Logistic regression analysis was used to analyze the impact of 25(OH)D level on the occurrence and recurrence of BPPV.Results In the case group,108 patients had vitamin D deficiency,with a prevalence rate of 62.1%,which was higher than that in the control group(42.8%).The serum 25(OH)D level in the case group was significantly lower than that in the control group(P<0.001).In the case group,the serum 25(OH)D level in the BPPV recurrence group was significantly lower than that in the non-recurrence group(11.2μg/L vs 18.7μg/L),and the difference was statistically significant(P<0.001).Regression analysis indicated that vitamin D deficiency was associated with BPPV and recurrent BPPV,with OR values of 2.15(95%CI 1.30-4.32;P=0.006)and 5.16(95%CI 1.00-34.12;P=0.05),respectively.Conclusion The decrease in serum 25(OH)D level is associated with the occurrence and recurrence of BPPV.

关 键 词：25-羟基维生素D 特发性良性阵发性位置性眩晕 维生素D缺乏症 

分 类 号：R741.041[医药卫生—神经病学与精神病学]