α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy  

作　　者：Qianhui Xu Huilan Wang Ruonan Yang Youqi Tao Ziying Wang Shengnan Zhang Bo Sun Dan Li Boxun Lu Cong Liu 

机构地区：[1]Interdisciplinary Research Center on Biology and Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai,China [2]University of Chinese Academy of Sciences,Beijing,China [3]State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,New Cornerstone Science Laboratory,School of Life Sciences,Fudan University,Shanghai,ChinaState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,New Cornerstone Science Laboratory,School of Life Sciences,Fudan University,Shanghai,China [4]Bio-X Institutes,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),Shanghai Jiao Tong University,Shanghai,China [5]School of Life Science and Technology,ShanghaiTech University,Shanghai,China [6]Zhangjiang Institute for Advanced Study,Shanghai Jiao Tong University,Shanghai,China [7]State Key Laboratory of Chemical Biology,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai,China

出　　处：《Cell Research》2025年第1期72-75,共4页细胞研究(英文版)

基　　金：supported by the National Natural Science Foundation(NSF)of China(82188101 and 32171236 to C.L.;92353302 and 32170683 to D.L.;81925012,92049301 to B.L.);the Science and Technology Commission of Shanghai Municipality(STCSM)(22JC1410400 to C.L.);the Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(JCYJ-SHFY-2022-005 to C.L.);the CAS Project for Young Scientists in Basic Research(YSBR-095 to C.L.);Shanghai Basic Research Pioneer Project to C.L,the Innovation Program of Shanghai Municipal Education Commission(2021-01-07-00-07.E00074 to B.L.).

摘　　要：Dear Editor,Parkinson’s disease(PD)is a progressive neurodegenerative disorder,which manifests through the abnormal accumulation of pathological amyloid fibrils composed of α-synuclein(α-syn)into Lewy bodies and the deterioration of dopaminergic neurons in the substantia nigra.1,2,3,4 In addition toα-syn fibrillar aggregation,the disruption of selective autophagy is also tightly linked to the pathogenesis of PD.5,6 The co-localization of LC3B,the key autophagosome protein in selective autophagy,7 andα-syn in the Lewy bodies of PD patients’brains points towards a potential role ofα-syn in modulating selective autophagy.8 Yet,the interplay between them has not been mechanistically elucidated.

关 键 词：AMYLOID LC3B selective 

分 类 号：R742.5[医药卫生—神经病学与精神病学]