瘢痕疙瘩中糖代谢的生物学意义  

Biological significance of glucose metabolism in keloids

作　　者：黄靖竣 王素洁 金升元 Huang Jingjun;Wang Sujie;Jin Shengyuan(Department of Plastic Surgery and Burn,Affiliated Hospital of Yanbian University,Yanji 133000,China)

机构地区：[1]延边大学附属医院整形烧伤科,延吉133000

出　　处：《中华整形外科杂志》2024年第12期1368-1372,共5页Chinese Journal of Plastic Surgery

摘　　要：瘢痕疙瘩常常伴有瘙痒、疼痛不适等临床表现, 具有与肿瘤类似的生物学特性导致瘢痕疙瘩难治愈、易复发。目前在瘢痕疙瘩形成的众多机制中发现细胞糖代谢的转变有着重要作用。该文归纳了瘢痕疙瘩中细胞糖代谢的研究进展, 解释了瘢痕疙瘩成纤维细胞通过有氧糖酵解代谢进行肿瘤样增殖的现象, 进一步探讨瘢痕疙瘩中内皮细胞与免疫细胞的代谢与炎症反应的关系对瘢痕疙瘩的影响, 并总结了瘢痕疙瘩中葡萄糖转运蛋白、乳酸脱氢酶及丙酮酸激酶的作用, 为瘢痕疙瘩的预防及治疗提供更多思路。Keloids are often accompanied by clinical manifestations such as itching,pain,and discomfort.Their biological characteristics bear similar to those of tumors,making keloids difficult to cure and prone to relapse.Recent research has identified a crucial role for alterations in cellular glucose metabolism in the pathogenesis of keloids.This paper summarized the research progress on cell glucose metabolism in keloids,explaining the tumor-like proliferation of keloid fibroblasts through aerobic glycolytic metabolism.Furthermore,it explored the influence of the relationship between endothelial cell and immune cell metabolism and inflammatory response on keloids.The roles of glucose transporter,lactate dehydrogenase,and pyruvate kinase in keloid were summarized here,providing more insights for the prevention and treatment of keloids.

关 键 词：瘢痕疙瘩 糖代谢 Warburg效应 炎症反应 葡萄糖转运蛋白 乳酸脱氢酶 丙酮酸激酶 

分 类 号：R73[医药卫生—肿瘤]