Biomaterial‑based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration  

作　　者：Ying-Ying Li Shuai-Fei Ji Xiao-Bing Fu Yu-Feng Jiang Xiao-Yan Sun 

机构地区：[1]Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department,Chinese PLA General Hospital and PLA Medical College,PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury,Repair and Regeneration,Research Unit of Trauma Care,Tissue Repair and Regeneration,Chinese Academy of Medical Sciences,2019RU051,Beijing 100048,China [2]Research Unit of Trauma Care,Tissue Repair and Regeneration,Chinese Academy of Medical Sciences,2019RU051,Beijing 100048,China 2Department of Tissue Regeneration and Wound Repair,Chinese PLA General Hospital,Beijing 100853,China

出　　处：《Military Medical Research》2025年第1期96-120,共25页军事医学研究(英文版)

基　　金：supported in part by the National Nature Science Foundation of China(92268206,81830064);the CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-059);the Military Medical Research Projects(145AKJ260015000X,2022-JCJQ-ZB-09600);the Military Key Basic Research of Foundational Strengthening Program(2020-JCJQ-ZD-256-021);the Science Foundation of National Defense Science and Technology for Excellent Young(2022-JCJQ-ZQ-017);the Military Medical Research and Development Projects(AWS17J005,2019-126);the Specific Research Fund of The Innovation Platform for Academicians of Hainan Province(YSPTZX202317).

摘　　要：Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages,ultimately impairing its normal physiological function.Accumulating evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration,promoting scarless repair by influencing the extracellular microenvironment and driving the phenotypic transitions.The field of skin repair and skin appendage regeneration has witnessed remarkable advancements in the utilization of biomaterials with distinct physical properties.However,a comprehensive understanding of the underlying mechanisms remains somewhat elusive,limiting the broader application of these innovations.In this review,we present two promising biomaterial-based mechanical approaches aimed at bolstering the regenerative capacity of compromised skin.The first approach involves leveraging biomaterials with specific biophysical properties to create an optimal scarless environment that supports cellular activities essential for regeneration.The second approach centers on harnessing mechanical forces exerted by biomaterials to enhance cellular plasticity,facilitating efficient cellular reprogramming and,consequently,promoting the regeneration of skin appendages.In summary,the manipulation of mechanical cues using biomaterial-based strategies holds significant promise as a supplementary approach for achieving scarless wound healing,coupled with the restoration of multiple skin appendage functions.

关 键 词：SCARLESS Wound healing Biomaterials Mechanical cues Skin appendages 

分 类 号：R318.08[医药卫生—生物医学工程]