小胶质细胞糖代谢重编程在中枢神经系统疾病中的研究进展  

Research advances in microglial glucose metabolic reprogramming in central nervous system diseases

作　　者：白凌云 抗晶晶(综述)[2] 曹翔(审校) BAI Lingyun;KANG Jingjing;CAO Xiang(Institute of Life and Health,Nanjing Drum Tower Hospital,Nanjing Normal University,Nanjing 210008,China)

机构地区：[1]南京师范大学鼓楼医院生命健康研究院,江苏南京210008 [2]黄河科技学院医学院生化教研室,河南郑州450063

出　　处：《中风与神经疾病杂志》2025年第1期65-69,共5页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金(82371326,82171310);江苏省优秀青年基金项目(BK20240118)。

摘　　要：小胶质细胞作为脑内的巨噬细胞,受到中枢神经系统微环境的严格调控。在应对各种类型的环境和细胞应激的反应中,小胶质细胞迅速激活并表现出促炎或抗炎表型以维持脑组织的稳态,在此过程中,可以明显地观察到小胶质细胞的糖代谢变化。有氧糖酵解是促炎型小胶质细胞的主要细胞供能方式,而抗炎型小胶质细胞则利用氧化磷酸化为其提供能量。本文系统地阐述了小胶质细胞的糖代谢和糖代谢重编程途径,以及其糖代谢重编程在中枢神经系统疾病中发挥的作用。此外,我们还探讨了靶向小胶质细胞糖代谢重编程治疗相关疾病的潜力。Serving as cerebral macrophages,microglial cells are meticulously regulated by the microenvironment of the central nervous system.In response to various environmental and cellular stresses,microglial cells are rapidly activated and exhibit either pro-inflammatory or anti-inflammatory phenotypes to maintain brain tissue homeostasis,and during this process,significant changes are observed in glucose metabolism of microglial cells.Aerobic glycolysis is the primary energy source for pro-inflammatory microglial cells,while oxidative phosphorylation is the energy source for anti-inflammatory microglial cells.This article systematically elaborates on glucose metabolism and glucose metabolic reprogramming pathways in microglial cells,as well as their role in central nervous system diseases.In addition,this article also discusses the potential of targeting glucose metabolic reprogramming in microglial cells for the treatment of related diseases.

关 键 词：小胶质细胞 糖代谢 糖代谢重编程 中枢神经系统疾病 

分 类 号：R741.02[医药卫生—神经病学与精神病学]