线粒体调节的Tregs:中枢神经系统自身免疫性疾病潜在治疗靶点的研究进展  

Mitochondrial-regulated Tregs:Research advances in potential therapeutic targets for autoimmune diseases of the central nervous system

作　　者：韩奥娅 彭婷婷 谢银银 张婉婉 孙文琳 谢祎 马蕴青 王翠(综述)[2] 谢南昌(审校)[1] HAN Aoya;PENG Tingting;XIE Yinyin(Department of Neurology,The First Affili-ated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院神经内科,河南郑州450052 [2]郑州大学第一附属医院检验科,河南郑州450052

出　　处：《中风与神经疾病杂志》2025年第1期70-76,共7页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金(81971214)。

摘　　要：调节性T细胞(Tregs)具有清除自身反应性淋巴细胞、诱导自身耐受和抑制炎症反应的功能。线粒体作为细胞的能量工厂,对Tregs的功能、分化和存活至关重要。研究表明中枢神经系统自身免疫性疾病如多发性硬化、视神经脊髓炎谱系疾病、自身免疫性脑炎等均存在Tregs异常和线粒体损伤,但线粒体调节的Tregs在中枢神经系统自身免疫性疾病中的作用尚无定论。因此,本文综述了中枢神经系统自身免疫背景下线粒体损伤对Tregs的调节以及未来可能的线粒体治疗靶点。Regulatory T cells(Tregs)can clear autoreactive lymphocytes,induce self-tolerance,and suppress in-flammatory response.As the energy factories of cells,mitochondria are critical for the function,differentiation,and sur-vival of Tregs.Studies have found Treg abnormalities and mitochondrial damage in patients with central nervous system au-toimmune diseases,such as multiple sclerosis,neuromyelitis optica spectrum disorder,and autoimmune encephalitis.However,the role of mitochondrial-regulated Tregs in central nervous system autoimmune diseases remains inconclusive.Therefore,this review focuses on the effects of mitochondrial damage on Tregs in central nervous system autoimmune dis-eases and the possible mitochondrial therapeutic targets.

关 键 词：线粒体 调节性T细胞 中枢神经系统自身免疫性疾病 FOXP3 

分 类 号：R741.02[医药卫生—神经病学与精神病学] R593.2[医药卫生—临床医学]