食管黏液表皮样癌86例临床病理特征及预后  

Clinicopathological characteristics and prognosis of 86 cases of esophageal mucoepidermoid carcinoma

作　　者：赵若华 宋昕[1] 赵学科[1] 秦富强 李爱丽[4] 王献增 王五洲 郭威 李吉林 马磊[8] 徐全晓[8] 孙慧[1,2] 蒋宁宁 丁倩倩 朱佳仪 李秀敏 鲍启德[10] 库建伟[11] 张冬云[12] 纪爱芳[13] 王立东[1] ZHAO Ruohua;SONG Xin;ZHAO Xueke;QIN Fuqiang;LI Aili;WANG Xianzeng;WANG Wuzhou;GUO Wei;LI Jilin;MA Lei;XU Quanxiao;SUN Hui;JIANG Ningning;DING Qianqian;ZHU Jiayi;LI Xiumin;BAO Qide;KU Jianwei;ZHANG Dongyun;JI Aifang;WANG Lidong(Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention&Treatment of the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;School of Medical Sciences,Zhengzhou University,Zhengzhou 450052;Department of Ophthalmology,Linzhou Tumor Hospital,Linzhou,Henan 456550;Department of Oncology,Linzhou Tumor Hospital,Linzhou,Henan 456550;Department of Thoracic Surgery,Linzhou People′s Hospital,Linzhou,Henan 456550;Department of Neurology,Linzhou People′s Hospital,Linzhou,Henan 456550;Department of Pathology,Linzhou People′s Hospital,Linzhou,Henan 456550;Tumor Laboratory,the First People′s Hospital of Nanyang,Nanyang,Henan 473000;Xinxiang Key Laboratory of Tumor Molecular Therapy,Xinxiang Medical College,Xinxiang,Henan 453003;Department of Medical Oncology,Anyang Regional Hospital,Anyang,Henan 455000;Department of Oncology,the First Affiliated Hospital of Nanyang Medical College,Nanyang,Henan 473003;Department of Pathology,Nanyang Medical College,Nanyang,Henan 473000;Department of Clinical Laboratory,Heping Hospital Affiliated to Changzhi Medical College,Changzhi,Shanxi 046000)

机构地区：[1]郑州大学第一附属医院河南省食管癌重点开放实验室,代谢紊乱与食管癌防治全国重点实验室,郑州450052 [2]郑州大学医学科学院,郑州450052 [3]林州市肿瘤医院眼科,河南林州456550 [4]林州市肿瘤医院肿瘤科,河南林州456550 [5]林州市人民医院胸外科,河南林州456550 [6]林州市人民医院神经内科,河南林州456550 [7]林州市人民医院病理科,河南林州456550 [8]南阳市第一人民医院河南省肿瘤分子生物学医学重点实验室,河南南阳473000 [9]新乡医学院新乡市肿瘤分子治疗重点实验室,河南新乡453003 [10]安阳地区医院肿瘤内科,河南安阳455000 [11]南阳医学高等专科学校第一附属医院肿瘤科,河南南阳473003 [12]南阳医学高等专科学校基础医学部病理教研室,河南南阳473000 [13]长治医学院附属和平医院检验科,山西长治046000

出　　处：《郑州大学学报(医学版)》2025年第1期21-24,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家科技重大专项(2024ZD0520900,2024ZD05209060);国家自然科学基金项目(U1301227);河南省科技攻关项目(232102311032)。

摘　　要：目的:探讨食管黏液表皮样癌(EMEC)患者的临床病理特征及预后。方法:选择郑州大学第一附属医院河南省食管癌重点开放实验室70万例食管癌患者临床病理和随访(1973至今)大资料库中2001年1月至2020年12月确诊的86例原发性EMEC患者,男60例,女26例,年龄44~78岁。采用Kaplan-Meier法生存曲线并行Log-rank检验;采用Cox回归分析EMEC预后的影响因素。结果:有、无淋巴结转移患者,年龄≥65岁和<65岁患者生存曲线的差异均有统计学意义(P<0.05)。Cox回归结果显示年龄≥65岁[HR(95%CI)为2.357(1.300~4.274)]和有淋巴结转移[HR(95%CI)为2.262(1.275~4.012)]是EMEC患者预后的危险因素。结论:年龄和淋巴结转移是EMEC预后的影响因素。Aim:To investigate the clinicopathological characteristics and prognostic factors of esophageal mucoepidermoid carcinoma(EMEC).Methods:A total of 86 patients diagnosed with EMEC between January 2001 and December 2020 were selected from the database of clinicopathology and follow-up(since 1973)of 700000 cases of esophageal cancer patients in Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital,Zhengzhou University,including 60 males and 26 females,aged 44 to 78 years.Kaplan-Meier survival curves were drawn for patients with and without lymph node metastasis,and for patients with age≥65 and<65 years,followed by Log-rank test.Cox regression analysis was used to identify prognostic factors for EMEC.Results:The survival differences between patients with and without lymph node metastasis,and between patients with age≥65 and<65 years were statistically significant(P<0.05).Cox regression analysis revealed that age≥65 years[HR(95%CI)was 2.357(1.300-4.274)]and lymph node metastasis[HR(95%CI)was 2.262(1.275-4.012)]were risk factors for poor prognosis in EMEC.Conclusion:Age≥65 years and lymph node metastasis are risk factors for survival of EMEC.

关 键 词：食管黏液表皮样癌 临床病理特征 预后 

分 类 号：R735.1[医药卫生—肿瘤]