食管腺样囊性癌67例临床病理特征及预后  

Clinicopathological characteristics and prognosis of 67 cases of esophageal adenoid cystic carcinoma

作　　者：孙慧[1,2] 宋昕 赵若华[1,2] 蒋宁宁 朱佳仪 丁倩倩 赵学科 范宗民[1] 李爱丽[3] 张冬云[4] 马磊[5] 裘一兵[6] 纪爱芳 王立东[1] SUN Hui;SONG Xin;ZHAO Ruohua;JIANG Ningning;ZHU Jiayi;DING Qianqian;ZHAO Xueke;FAN Zongmin;LI Aili;ZHANG Dongyun;MA Lei;QIU Yibing;JI Aifang;WANG Lidong(Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention&Treatment of the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;School of Medical Sciences,Zhengzhou University,Zhengzhou 450052;Department of Oncology,Linzhou Tumor Hospital,Linzhou,Henan 456550;Department of Pathology,Nanyang Medical College,Nanyang,Henan 473000;Tumor Laboratory,the First People′s Hospital of Nanyang,Nanyang,Henan 473000;Henan Institute of Medical and Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450052;Department of Clinical Laboratory,Heping Hospital Affiliated to Changzhi Medical College,Changzhi,Shanxi 046000)

机构地区：[1]郑州大学第一附属医院河南省食管癌重点开放实验室,代谢紊乱与食管癌防治全国重点实验室,郑州450052 [2]郑州大学医学科学院,郑州450052 [3]林州市肿瘤医院肿瘤科,河南林州456550 [4]南阳医学高等专科学校基础医学部病理教研室,河南南阳473000 [5]南阳市第一人民医院河南省肿瘤分子生物学医学重点实验室,河南南阳473000 [6]郑州大学河南省医药科学研究院,郑州450052 [7]长治医学院附属和平医院检验科,山西长治046000

出　　处：《郑州大学学报(医学版)》2025年第1期24-27,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家科技重大专项(2024ZD0520900,2024ZD05209060);国家自然科学基金项目(U1301227);河南省科技攻关项目(232102311032)。

摘　　要：目的:探讨食管腺样囊性癌(EACC)的临床病理特征及预后。方法:选择郑州大学第一附属医院河南省食管癌重点开放实验室70万例食管癌患者临床病理和随访(1973至今)大资料库中2001年10月至2023年6月确诊的67例EACC患者,其中男51例,女16例,发病年龄52~81岁。采用Kaplan-Meier法绘制生存曲线并行Log-rank检验。采用Cox回归分析EACC预后的影响因素。结果:无淋巴结转移患者的生存状况好于有淋巴结转移者(P<0.05)。有淋巴结转移[HR(95%CI)为3.875(1.607~9.342)]是EACC预后的危险因素。结论:淋巴结转移是EACC预后的影响因素。Aim:To investigate the clinicopathological characteristics and prognosis of esophageal adenoid cystic carcinoma(EACC).Methods:A total of 67 patients with EACC diagnosed from October 2001 to June 2023 were selected from the database of clinicopathology and follow-up(since 1973)of 700000 cases of esophageal cancer patients in Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital,Zhengzhou University,including 51 males and 16 females,with the age of onset of disease ranging from 52 to 81 years.Survival curves were plotted using Kaplan-Meier method,and the differences between the 2 groups were compared by Log-rank test.Cox regression was used to analyze the factors influencing the prognosis of EACC.Results:The survival of patients without lymph node metastasis was better than those with lymph node metastasis(P<0.05).Lymph node metastasis[HR(95%CI)was 3.875(1.607-9.342)]was a risk factor affecting the prognosis of EACC.Conclusion:Lymph node metastasis is an influential factor for the prognosis of EACC.

关 键 词：食管腺样囊性癌 临床病理特征 预后 

分 类 号：R735.1[医药卫生—肿瘤]