Association between Fish Consumption and Stroke Incidence Across Different Predicted Risk Populations:A Prospective Cohort Study from China  

作　　者：Hongyue Hu Fangchao Liu Keyong Huang Chong Shen Jian Liao Jianxin Li Chenxi Yuan Ying Li Xueli Yang Jichun Chen Jie Cao Shufeng Chen Dongsheng Hu Jianfeng Huang Xiangfeng Lu Dongfeng Gu 

机构地区：[1]Department of Epidemiology,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing 211166,Jiangsu,China [2]Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China [3]Key Laboratory of Cardiovascular Epidemiology,Chinese Academy of Medical Sciences,Beijing 100037,China [4]Research Units of Cohort Study on Cardiovascular Diseases and Cancers,Chinese Academy of Medical Sciences,Beijing 100730,China [5]School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen 518055,Guangdong,China [6]Department of Occupational and Environmental Health,School of Public Health,Tianjin Medical University,Tianjin 300070,China [7]Department of Epidemiology and Health Statistics,College of Public Health,Zhengzhou University,Zhengzhou 450001,Henan,China [8]Department of Epidemiology and Health Statistics,School of Public Health,Shenzhen University Health Science Center,Shenzhen 518071,Guangdong,China

出　　处：《Biomedical and Environmental Sciences》2025年第1期15-26,共12页生物医学与环境科学(英文版)

基　　金：supported by the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2021-I2M-1-010,2019-I2M-2-003,and 2017-I2M-1-004);the National High Level Hospital Clinical Research Funding(2022-GSPGG-1,2022-GSP-GG-2);the Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancers,CAMS(2019RU038);the National Key Research and Development Program of China(2018YFE0115300 and 2017YFC0211700);the National Natural Science Foundation of China(82030102,12126602).

摘　　要：Objective The relationship between fish consumption and stroke is inconsistent,and it is uncertain whether this association varies across predicted stroke risks.Methods A cohort study comprising 95,800 participants from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project was conducted.A standardized questionnaire was used to collect data on fish consumption.Participants were stratified into low-and moderate-to-high-risk categories based on their 10-year stroke risk prediction scores.Hazard ratios(HRs)and 95%confidence intervals(CIs)were estimated using Cox proportional hazard models and additive interaction by relative excess risk due to interaction(RERI),attributable proportion(AP),and synergy index(SI).Results During 703,869 person-years of follow-up,2,773 incident stroke events were identified.Higher fish consumption was associated with a lower risk of stroke,particularly among moderate-to-high-risk individuals(HR=0.53,95%CI:0.47-0.60)than among low-risk individuals(HR=0.64,95%CI:0.49-0.85).A significant additive interaction between fish consumption and predicted stroke risk was observed(RERI=4.08,95%CI:2.80-5.36;SI=1.64,95%CI:1.42-1.89;AP=0.36,95%CI:0.28-0.43).Conclusion Higher fish consumption was associated with a lower risk of stroke,and this beneficial association was more pronounced in individuals with moderate-to-high stroke risk.

关 键 词：Fish consumption STROKE Predicted stroke risk Cohort study INTERACTION 

分 类 号：R743.3[医药卫生—神经病学与精神病学]