SNARE复合物在自噬及相关疾病中的研究进展  

Research progress of SNARE complex in autophagy and related diseases

作　　者：李彩银 刘源[1,2] 郭柔佳 卜晶晶 闫向丽 栗俞程 LI Caiyin;LIU Yuan;GUO Roujia;BU Jingjing;YAN Xiangli;LI Yucheng(Collaborative Innovation Center of Henan Province,Henan University of Chinese Medicine,Henan Key Laboratory for Modern Research on Zhongjing's Herbal Formulae,Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046,China;College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学豫药全产业链研发河南省协同创新中心,河南中医药大学中医药科学院,河南省仲景方药现代研究重点实验室,河南郑州450046 [2]河南中医药大学药学院,河南郑州450046

出　　处：《中国病理生理杂志》2025年第1期188-194,共7页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.82304771);河南省自然科学基金资助项目(No.202300410249);河南省联合基金重点项目(No.232301420018)。

摘　　要：自噬是真核生物中普遍存在的一种保守的生理现象,在饥饿或营养缺乏时通过降解细胞内的蛋白质和细胞器以促进细胞存活。自噬功能障碍与多种疾病密切相关。可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体(soluble N-elthylmaleimide-sensitive factor attachment protein receptor,SNARE)复合物是一种介导膜融合的蛋白质,在自噬体和溶酶体的融合过程中发挥关键作用。SNARE复合物组装异常可引起自噬流阻滞,进而导致细胞功能紊乱和疾病的发生。本文对SNARE复合物在自噬过程的作用,以及在相关疾病中的最新研究进行总结,为以SNARE复合物为靶点研究自噬和疾病的机制提供参考。Autophagy is a conserved physiological phenomenon commonly found in all eukaryotic cells,which promotes cell survival by degrading intracellular proteins and organelles during starvation or nutrient deficiency.Dysfunction autophagy is closely related to various diseases.Soluble N-elthylmaleimide-sensitive factor attachment protein receptor(SNARE)complex is a protein complex that mediates membrane fusion and plays a key role in the fusion process of autophagosomes and lysosomes.The aberrant assembly of the SNARE complex results in the arrest of autophagic flow,thereby leading to cellular dysfunction and the occurrence of diseases.In this review,we summarized the roles of SNARE proteins in the autophagosome-lysosome fusion and the latest research in related diseases,providing a reference for studying the mechanism of autophagy and diseases targeting the SNARE complex.

关 键 词：SNARE复合物 自噬 自噬体 溶酶体 

分 类 号：R741[医药卫生—神经病学与精神病学] R730.23[医药卫生—临床医学] R363