埃兹蛋白在糖脂代谢中作用的研究进展  

Progress in role of ezrin in glucose and lipid metabolism

作　　者：顾杨怡 徐亭亭[4] 常岑 李黎 GU Yangyi;XU Tingting;CHANG Cen;LI Li(Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200052,China;Institute of Arthritis Research in Integrative Medicine,Shanghai Academy of Traditional Chinese Medicine,Shanghai 200052,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海中医药大学附属光华医院,上海200052 [2]上海市中医药研究院中西医结合关节炎研究所,上海200052 [3]上海中医药大学,上海201203 [4]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《中国病理生理杂志》2025年第1期202-208,共7页Chinese Journal of Pathophysiology

基　　金：上海市自然基金资助项目(No.23ZR1453800);上海市“科技创新行动计划”启明星项目(扬帆计划)(No.23YF1436300);上海市卫生健康委员会临床专项(No.201940364);长宁区卫生健康委员会临床专项(No.20214Z003)。

摘　　要：埃兹蛋白(ezrin)是ezrin-radixin-moesin蛋白家族的重要成员,也是肌动蛋白细胞骨架和质膜之间的关键连接者。磷酸化是其主要的翻译后修饰方式。ezrin主要存在于上皮细胞中,具有多种生物学功能,在维持细胞形态、参与细胞运动、调控信号转导、影响细胞力学性能等方面发挥着重要作用。近年来大量研究证明了ezrin参与糖脂代谢,并且与糖脂代谢性疾病的发生发展密切相关。本文主要回顾了ezrin在糖脂代谢中的作用及其近期的研究进展,为对ezrin蛋白未来的探索提供新的方向。Ezrin is a crucial member of the ezrin-radixin-moesin protein family,serving as a vital connector between the actin cytoskeleton and the plasma membrane.Its primary post-translational modification occurs through phosphorylation.Predominantly present in epithelial cells,ezrin has a wide range of biological functions.It plays a key role in maintaining cell morphology,participating in cell motility,regulating signal transduction,and influencing the mechanical properties of cells.Recently,numerous studies have demonstrated the involvement of ezrin in glucose and lipid metabolism,which are closely linked to the development of glucolipid metabolic diseases.This review evaluates the role of ezrin in glucose and lipid metabolism,discusses recent research progress,and outlines new directions for future studies.

关 键 词：埃兹蛋白 糖代谢 脂代谢 肌动蛋白结合蛋白 磷酸化 

分 类 号：R363[医药卫生—病理学] R589[医药卫生—基础医学] Q493.4[生物学—生理学]