NFE2L2 and ferroptosis resistance in cancer therapy  

作　　者：Daolin Tang Rui Kang 

机构地区：[1]Department of Surgery,University of Texas Southwestern Medical Center,Dallas,TA 75390,USA

出　　处：《Cancer Drug Resistance》2024年第1期273-296,共24页癌症耐药(英文)

基　　金：supported by grants from the National Institutes of Health of USA(R01CA160417,R01CA229275,and R01CA211070).

摘　　要：NFE2-like basic leucine zipper transcription factor 2(NFE2L2,also known as NRF2),is a key transcription factor in the cellular defense against oxidative stress,playing a crucial role in cancer cell survival and resistance to therapies.This review outlines the current knowledge on the link between NFE2L2 and ferroptosis-a form of regulated cell death characterized by iron-dependent lipid peroxidation-within cancer cells.While NFE2L2 activation can protect normal cells from oxidative damage,its overexpression in cancer cells contributes to drug resistance by upregulating antioxidant defenses and inhibiting ferroptosis.We delve into the molecular pathways of ferroptosis,highlighting the involvement of NFE2L2 and its target genes,such as NQO1,HMOX1,FTH1,FTL,HERC2,SLC40A1,ABCB6,FECH,PIR,MT1G,SLC7A11,GCL,GSS,GSR,GPX4,AIFM2,MGST1,ALDH1A1,ALDH3A1,and G6PD,in ferroptosis resistance.Understanding the delicate balance between NFE2L2’s protective and deleterious roles could pave the way for novel therapeutic strategies targeting NFE2L2 to enhance the efficacy of ferroptosis inducers in cancer therapy.

关 键 词：Cancer therapy drug resistance ferroptosis NFE2L2 oxidative stress 

分 类 号：R73[医药卫生—肿瘤]