不同湿化方法对喉癌患者术后气道湿化效果的网状Meta分析  

Effects of airway humidification for postoperative with laryngeal cancer:A network Meta-analysis

作　　者：马莎莎[1] 谷月 MA Shasha;GU Yue(Department of Neurosurgery,Binzhou Medical University Hospital,Binzhou 256600,China;Department of Geriatrics,Yantai Affiliated Hospital of Binzhou Medical University,Yantai 264000,China)

机构地区：[1]滨州医学院附属医院神经外科,山东滨州256600 [2]滨州医学院烟台附属医院老年医学科,山东烟台264000

出　　处：《广州医药》2025年第1期89-98,共10页Guangzhou Medical Journal

基　　金：山东省自然科学基金面上项目(ZR2023MH378);山东省医药卫生青年项目(202314050473);滨州医学院科研计划与科研启动基金项目(BY2020KJ39);滨州医学院附属医院护理“新苗项目”科研立项(BYFYHL-XM20220D)。

摘　　要：目的 评估多种气道湿化方法对喉癌患者术后气道湿化的效果。方法 检索PubMed、Cochrane、Embase、Web of Science、Ovid、中国知网、万方、CBM、Google Scholar等数据库和网站,检索时限为建库至2023年2月。搜集关于喉癌患者术后不同气道湿化方法的随机对照试验,采用JBI2016年随机对照试验RCT评价标准评价文献质量。使用ADDIS1.16.5软件进行网状Meta分析。结果 纳入18篇研究,共1 596例患者。结果显示,镇痛泵持续泵入与注射器间断滴入、喷雾瓶间断喷雾在痰痂形成方面比较差异有统计学意义[OR(95%CI)=537.70(4.18,124 511.88)、0(0,0.52),P<0.05];湿化满意度方面,注射器间断滴入与喷雾瓶间断喷雾比较差异有统计学意义[OR(95%CI)=8.55(1.40,73.35),P<0.05];其余比较差异无统计学意义(P>0.05)。概率排序显示,降低肺部感染、黏膜出血和痰痂形成、痰液黏稠度、咳嗽和湿化不满意的发生,最优方法分别为湿化泵持续泵入、镇痛泵持续泵入、MR400湿化器和输液器持续泵入。结论 综合网状Meta分析及概率排序结果,考虑到喉癌患者术后早期下床活动,推荐便携式持续湿化方法。Objective To access the effects of multiple airway humidification methods for postoperative patients with laryngeal cancer.Methods PubMed,Cochrane Library,EMbase,Web of Science,Ovid,China National Knowledge Infrastructure,Wanfang database,CBM and Google Scholar were searched systematically from establishment to February 2023,respectively.Related randomized controlled trials on airway humidification for postoperative patients with laryngeal cancer was analyzed and the quality of the literature was assessed using the JBI 2016 RCT evaluation.The network Meta analysis was performed using ADDIS 1.16.5 softwares.Results A total of 18 articles and 1596 patients were inciuded.The results showed that the analgesia pump continued to pump into the airway compared with the syringe intermittently drip and the spray bottle intermittent spray was statistically different in the formation of sputum[OR(95%CI)=537.70(4.18,124511.88),0(0,0.52),P<0.05].In terms of satisfaction of wetness,the difference between the intermittent drop of the syringe and the intermittent spray of the spray bottle was statistically different[OR(95%CI)=8.55(1.40,73.35),P<0.05],the others were not statistically different(P>0.05).Probability ranking table shows that the optimal methods were the humidification pump continues to pump into the airway,the analgesia pump continued to pump into the airway,the MR400 humidifier and the infusion set continuously pumped into the airway,which were beneficial to the reduction in pulmonary infection,tracheal mucosal hemorrhage and formation of phlegm callus,the degree of sputum viscosity,cough and unsatisfactory wetness.Conclusions Based on the comprehensive mesh meta-analysis and probability ranking results,a portable continuous humidification method is recommended considering the early post-operative activities of laryngeal cancer patients.

关 键 词：喉癌 术后 气管切开 湿化方法 网状Meta分析 

分 类 号：R739.65[医药卫生—肿瘤]