AST、CHE、CA125、AFP对肝硬化患者的诊断效果分析  

Analysis of diagnostic efficacy of AST,CHE,CA125 and AFP in patients with liver cirrhosis

作　　者：文亚平 张志杰 刘婷[1] WEN Yaping;ZHANG Zhijie;LIU Ting(Department of laboratory,MedicineSouth China University Affiliated Changsha Central Hospital,Changsha 410008,China)

机构地区：[1]南华大学附属长沙中心医院检验科,湖南长沙410008

出　　处：《广州医药》2025年第1期113-116,130,共5页Guangzhou Medical Journal

摘　　要：目的分析谷草转氨酶(AST)、胆碱酯酶(CHE)、糖类抗原125(CA125)以及甲胎蛋白(AFP)对肝硬化患者的诊断效能。方法选择70例肝硬化患者为观察组研究对象,另取70例同期健康体检者为对照组。两组研究对象均接受生化检验、肿瘤标志物检验。对比两组研究对象的AST、CHE、CA125、AFP检测结果,分析上述指标对肝硬化患者的诊断效能。结果观察组肝硬化患者的CHE低于对照组,AST、CA125与AFP高于对照组(P<0.05);AST与CHE在肝硬化诊断中具有良好的灵敏度、特异度;CA125联合AFP的灵敏度、特异度、符合率均高于CA125或AFP单独检验(P<0.05)。结论AST、CHE、CA125、AFP在肝硬化患者临床诊断中具有良好的应用表现,是反映患者肝硬化病情进展的重要参考指标。Objective To analyze the diagnostic efficacy of aspartate aminotransferase(AST),cholinesterase(CHE),carbohydrate antigen 125(CA125),and alpha fetoprotein(AFP)in patients with liver cirrhosis.Methods A total of 70 patients with liver cirrhosis were included in the observation group as the study subjects,and 70 healthy individuals who underwent physical examinations during the same period were selected as the control group.Both groups of research subjects underwent biochemical testing and tumor marker testing.The AST,CHE,CA125,and AFP detection results of two groups of research subjects were compared,and the diagnostic effect of the above indicators on patients with liver cirrhosis were analyzed.Results The CHE test results of patients with liver cirrhosis in the observation group were significantly lower than those of healthy individuals undergoing physical examination,and the AST,CA125,and AFP test results were higher(P<0.05).AST and CHE had good sensitivity and specificity in the diagnosis of liver cirrhosis.The sensitivity,specificity and coincidence rate of CA125 combined with AFP were higher than those of CA125 or AFP alone.Conclusions AST,CHE,CA125,and AFP have good clinical application performance in the diagnosis of liver cirrhosis patients,and are important reference indicators reflecting the progression of liver cirrhosis in patients.

关 键 词：谷草转氨酶 胆碱酯酶 糖类抗原125 甲胎蛋白 肝硬化 

分 类 号：R575.2[医药卫生—消化系统]