头颈部脂肪肉瘤预后相关因素分析  

Prognostic Factors of Liposarcoma in Head and Neck

作　　者：丁硕 黄志刚[1,2] 房居高[1,2] 张洋[1,2] 侯丽珍[1,2] 郭伟[1,2] 尹高菲 钟琦[1,2] DING Shuo;HUANG Zhigang;FANG Jugao;ZHANG Yang;HOU Lizhen;GUO Wei;YIN Gaofei;ZHONG Qi(Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Key Laboratory of Otolaryngology Head and Neck Surgery(Capital Medical University),Ministry of Education,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京100730 [2]耳鼻咽喉头颈科学教育部重点实验室(首都医科大学),北京100730

出　　处：《肿瘤防治研究》2025年第1期31-35,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(82071032);北京市科技新星计划(20230484484)

摘　　要：目的探讨头颈部区域脂肪肉瘤的发病以及预后影响因素,同时分析不同治疗方案的疗效。方法回顾性分析2008年1月至2024年1月本院接治的头颈部脂肪肉瘤患者。所有患者均接受随访,利用SPSS软件分析患者预后。结果共纳入患者30例,其中脂肪肉瘤在眼眶内可达60%,其余脂肪肉瘤主要分布在颈深部各个间隙中。去分化脂肪肉瘤(33%)最常见,黏液多形性脂肪肉瘤(4%)最少见。肿瘤病理类型(P<0.001)和Ki67(P=0.014)对肿瘤控制率有显著影响。针对肿瘤的疾病特异性生存率进行分析,显示各项因素间差异无统计学意义(均P>0.05)。结论头颈部脂肪肉瘤的预后相对于其他部位的脂肪肉瘤预后更好,但黏液多形性脂肪肉瘤或多形性脂肪肉瘤以及Ki67过高是预后差的信号,而术后的辅助放射治疗并不能显著提高疾病特异性生存率。Objective To explore the pathogenesis and prognostic factors of liposarcoma in the head and neck region,and simultaneously analyze the efficacy of different treatment regimens.Methods A retrospective analysis was performed on all patients with primary untreated head and neck liposarcoma who were diagnosed and underwent surgical treatment at our hospital from January 2008 to January 2024.All patients were monitored during follow-up,and their prognoses were analyzed using SPSS software.Results A total of 30 patients were included in the study.Liposarcoma accounted for up to 60%of the cases in the orbit,while the remaining liposarcomas were primarily located in various interspaces of the neck.Dedifferentiated liposarcoma was the most common type,comprising 33%,while myxoid pleomorphic liposarcoma was the rarest at 4%.The tumor pathological type(P<0.001)and Ki67(P=0.014)significantly affected the tumor control rate.However,an analysis of disease-specific survival rates revealed no significant differences across various factors(all P>0.05).Conclusion The prognosis of head and neck liposarcoma is better compared to that of liposarcomas in other parts of the body.However,myxoid pleomorphic liposarcoma,pleomorphic fat sarcoma,and high Ki67 levels are indicators of poor prognosis.Additionally,postoperative adjuvant radiotherapy does not significantly enhance disease-specific survival rates.

关 键 词：头颈 脂肪肉瘤 预后分析 治疗 

分 类 号：R730.262[医药卫生—肿瘤]