妊娠期糖尿病与儿童注意缺陷多动障碍的关系及预测模型研究  

Study on the relationship between gestational diabetes mellitus and attention deficit hyperactivity disorder in children and its predictive model

作　　者：夏建锋[1] 缪伶伶 张晓鸥[1] 陈钰湘 XIA Jianfeng;MIAO Lingling;ZHANG Xiaoou;CHEN Yuxiang(Department of Pediatrics,Rugao People's Hospital,Rugao 226500,Jiangsu,China)

机构地区：[1]如皋市人民医院儿科,江苏如皋226500

出　　处：《贵州医科大学学报》2025年第1期121-126,133,共7页Journal of Guizhou Medical University

基　　金：国家卫生计生委医药卫生科技发展研究项目(W2016EWJS23);如皋市科技公关计划项目[SRGS(23)005]。

摘　　要：目的 分析妊娠期糖尿病与儿童注意缺陷多动障碍(attention deficit and hyperactivity disorder,ADHD)发生关系及预测模型研究。方法 选取门诊诊治的ADHD患儿120例设为研究组,根据ADHD父母评定量表再将研究组分为病情轻度组、病情中度组及病情重度组;于患儿入组后,记录并采用χ^(2)检验比较不同病情患儿其母妊娠期糖尿病发生情况,另选同时段来院检查的健康儿童120例作为对照组,收集所有受试者相关资料;采用logistic单因素、多因素分析影响ADHD发病的因素;探讨妊娠期糖尿病与ADHD发生关系;建立受试者工作特征(ROC)曲线下面积(AUC)评估妊娠期糖尿病预测ADHD发生的效能。结果 母亲妊娠期糖尿病发生率比较,重度组>中度组>轻度组和对照组,差异有统计学意义(P<0.05);研究组存在妊娠期糖尿病、妊娠期肥胖占比,父亲文化程度、母亲文化程度初中及以下占比,教育方式为训斥/批评占比均高于对照组,差异有统计学意义(P<0.05);logistic回归分析结果显示,妊娠期糖尿病、妊娠期肥胖、父亲文化程度、母亲文化程度、教育方式为ADHD发病的相关影响因素,妊娠期糖尿病及基于妊娠期糖尿病构建的ADHD发病预测模型预测ADHD发病的AUC分别为0.617、0.806。结论 妊娠期糖尿病增加ADHD风险,其预测模型对预测ADHD发病具有一定的参考价值。Objective To analyze the relationship between gestational diabetes mellitus and attention deficit hyperactivity disorder(ADHD) in children and relevant factors.Methods A total of 120 children diagnosed as ADHD and treated in the outpatient department of Rugao People's Hospital from June 2021 to November 2023 were selected as study group.According to ADHD parent rating scale,study group was divided into mild,moderate and severe groups.After the children were enrolled,incidence of gestational diabetes mellitus in their mothers was recorded and compared by χ~2 test.A total of 120 healthy children who came to our hospital for physical examination were selected as control group from June 2021 to November 2023.Relevant data of all subjects were collected.logistic univariate and multivariate analyses were used to identify the factors influencing the onset of ADHD.The relationship between gestational diabetes mellitus and ADHD was explored.Receiver operating characteristic(ROC) curve was established to evaluate the efficacy of gestational diabetes mellitus in predicting ADHD.Results The incidence of gestational diabetes mellitus was in severe group greater than in moderate group greater than in mild and control groups(P<0.05).The proportions of gestational diabetes mellitus and gestational obesity,the proportion of paternal education level,the proportion of maternal education level with middle school or below and the proportion of taking reprimand/criticism as education style were higher in study group than those in control group(P<0.05).logistic regression analysis showed that gestational diabetes mellitus,gestational obesity,paternal education level,maternal education level and educational style were the onset of ADHD-related influencing factors.The area under the curve(AUCs) of gestational diabetes mellitus and the prediction model of ADHD based on gestational diabetes mellitus in predicting the incidence of ADHD were 0.617 and 0.806,respectively.Conclusion Gestational diabetes mellitus increases the risk of ADHD,and

关 键 词：妊娠期糖尿病 儿童注意缺陷多动障碍 发生 病情严重程度 影响因素 

分 类 号：R749.94[医药卫生—神经病学与精神病学]