基于随机对照试验的铁皮枫斗颗粒改善亚健康人群免疫力的作用研究  

Study on the Effect of Tiepi Fengdou Granules on Improvement of Immunity in Sub-healthy People Based on Randomized Controlled Trial

作　　者：潘海涛 赵栋[3] 沈郁 杨继鸿 李振皓 PAN Haitao;ZHAO Dong;SHEN Yu;YANG Jihong;LI Zhenhao(Zhejiang Shouxiangu Botanical Drug Institute Co.,Ltd.,Hangzhou 311100,China;Hangzhou Yuhang Boyu Intelligent Health Innovation Lab,Hangzhou 311100,China;Zhejiang Center for Disease Control and Prevention,Hangzhou 310057,China;Zhejiang Engineering Research Center of Rare Medicinal Plants,Jinhua 321200,China)

机构地区：[1]浙江寿仙谷植物药研究院有限公司,杭州311100 [2]杭州市余杭区伯宇智慧健康研究院,杭州311100 [3]浙江省疾病预防控制中心,杭州310057 [4]浙江省珍稀植物药工程技术研究中心,浙江金华321200

出　　处：《中国现代应用药学》2024年第23期3310-3315,共6页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省重点农业企业研究院项目(2017Y20001)。

摘　　要：目的评价铁皮枫斗颗粒(Tiepi Fengdou granules,TFG)对亚健康人群免疫力的改善效果。方法采用随机对照试验,在杭州、湖州两地纳入111名40~65岁的亚健康人群为研究对象,随机分为观察组(服用TFG)和对照组,干预时间为3个月,在干预前后通过问卷调查一般健康情况,采集外周静脉血测量免疫相关生物指标;采用logistic线性回归模型,调整年龄、性别、疾病史、疫苗接种和身体质量指数(body mass index,BMI)等后,比较TFG干预对免疫相关生物指标的影响。结果本研究共纳入观察组56人,对照组55人,2组在年龄、性别、疾病史、疫苗接种等方面均无统计学差异;经调整年龄、性别、BMI后,干预后的观察组白细胞、中性粒细胞、淋巴细胞的绝对值和补体C3、C4的浓度均显著高于对照组(P<0.05)。结论TFG通过加强细胞免疫和补体系统改善亚健康人群的免疫力。OBJECTIVE To evaluate the improvement effect of Tiepi Fengdou granules(TFG)on the immunity of subhealthy people.METHODS A randomized controlled trial was conducted,a total of 111 sub-healthy people(40-65 years old)in Hangzhou and Huzhou were included in the study and randomly divided into observation group(eating TFG)and placebo group.The intervention time was 3 months.Before and after the intervention,the general health condition was investigated by questionnaire,and peripheral blood was collected to measure immune-related biological indicators.The logistic linear regression model was used to compare the effects of TFG intervention on immune-related biological indicators after adjusting for age,gender,disease history,and vaccination,and body mass index(BMI).RESULTS A total of 56 people in the observation group and 55 people in the placebo group were included in this study,and there were no statistically significant differences in age,gender,disease history,and vaccination between the two groups.After adjusting for age,gender and BMI,the absolute values of white blood cells,neutrophils,lymphocytes and the concentrations of complement C3 and C4 in observation group after treatment were significantly higher than those in placebo group(P<0.05).CONCLUSION TFG improves the immunity of sub-healthy people by strengthening cellular immunity and complement system.

关 键 词：铁皮枫斗颗粒 亚健康 细胞免疫 体液免疫 补体系统 

分 类 号：R969.4[医药卫生—药理学]