肺癌患者术后慢性疼痛发展轨迹的潜在剖面分析及其影响因素  

Potential Profile Analysis and Influencing Factors of Development Trajectory of Chronic Post-Surgery Pain in Patients with Lung Cancer

作　　者：王玲 李茸 朱丽[1] WANG Ling;LI Rong;ZHU Li(Oncology Radiotherapy Department,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院肿瘤放疗科,陕西省西安市710061

出　　处：《实用心脑肺血管病杂志》2025年第3期127-131,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：陕西省科技计划项目(2022SF-562)。

摘　　要：目的基于潜在剖面分析探讨肺癌患者术后慢性疼痛(CPSP)发展轨迹及其影响因素。方法选取2021年4月—2024年2月西安交通大学第一附属医院收治的伴有CPSP的肺癌患者178例为调查对象。分别采用一般资料调查表、数字分级评分量表(NRS)、医院焦虑抑郁量表(HADS)、疼痛灾难化量表(PCS)调查患者一般资料、疼痛程度、焦虑抑郁症状及疼痛灾难化水平。使用Mplus软件进行肺癌患者CPSP发展轨迹的潜在剖面分析并确定最佳剖面模型,肺癌患者CPSP发展轨迹的影响因素分析采用多因素Logistic回归分析。结果本研究共发放178份问卷,回收178份问卷,其中有效问卷166份,有效问卷回收率为93.3%(166/178)。根据潜在剖面分析结果显示,肺癌患者CPSP发展轨迹可分为3个潜在类别,分别为轻至完全缓解(n=87)、中至轻度疼痛(n=53)、高至中度疼痛(n=26)。不同CPSP发展轨迹患者性别、糖尿病发生率、高血压发生率、吗啡用量、手术时间、引流管留置时间、HADS评分、PCS评分比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,性别、吗啡用量、引流管留置时间、HADS评分、PCS评分是肺癌患者中至轻度疼痛的独立影响因素(P<0.05),性别、手术时间、引流管留置时间、HADS评分、PCS评分是肺癌患者高至中度疼痛的独立影响因素(P<0.05)。结论肺癌患者CPSP发展轨迹可分为3个潜在类别,分别为轻至完全缓解、中至轻度疼痛、高至中度疼痛;其中性别、吗啡用量、引流管留置时间、HADS评分、PCS评分是肺癌患者中至轻度疼痛的独立影响因素,性别、手术时间、引流管留置时间、HADS评分、PCS评分是肺癌患者高至中度疼痛的独立影响因素。Objective To explore the development trajectory and influencing factors of chronic post-surgery pain(CPSP)in patients with lung cancer based on potential profile analysis.Methods A total of 178 lung cancer patients with CPSP admitted to the First Affiliated Hospital of Xi'an Jiaotong University from April 2021 to February 2024 were selected as the survey subjects.The General Information Questionnaire,Numerical Rating Scale(NRS),Hospital Anxiety and Depression Scale(HADS)and Pain Catastrophizing Scale(PCS)were used to investigate the general information,pain degree,anxiety and depression symptoms and pain catastrophizing level of patients.The Mplus software was used to analyze the potential profile of the CPSP development trajectory of lung cancer patients and determine the best profile model.Multivariate Logistic regression analysis was used to analyze the influencing factors of the CPSP development trajectory of lung cancer patients.Results A total of 178 questionnaires were distributed in this study,and 178 questionnaires were collected,of which 166 were valid questionnaires,and the effective questionnaire recovery rate was 93.3%(166/178).According to the results of potential profile analysis,the development trajectory of CPSP in lung cancer patients can be divided into three potential categories:mild to complete remission(n=87),moderate to mild pain(n=53),and high to moderate pain(n=26).There were statistically significant differences in gender,incidence of diabetes,incidence of hypertension,morphine dosage,operation time,drainage tube indwelling time,HADS score and PCS score among patients with different CPSP development trajectory(P<0.05).Multivariate Logistic regression analysis showed that gender,morphine dosage,drainage tube indwelling time,HADS score and PCS score were independent influencing factors of moderate to mild pain in patients with lung cancer(P<0.05),gender,operation time,drainage tube indwelling time,HADS score and PCS score were independent influencing factors of high to moderate pain in pat

关 键 词：肺癌 术后慢性疼痛 发展轨迹 影响因素分析 

分 类 号：R734.2[医药卫生—肿瘤]