LLGL2蛋白在食管鳞癌组织中的表达及其临床意义  

Expression of LLGL2 Protein in Esophageal Squamous Cell Carcinoma and Its Clinical Significance

作　　者：孔欣 黄雪洁 张全武[1] KONG Xin;HUANG Xuejie;ZHANG Quanwu(Zhengzhou Central Hospital,Zhengzhou,450007)

机构地区：[1]河南省郑州市中心医院,450007

出　　处：《实用癌症杂志》2025年第1期72-74,共3页The Practical Journal of Cancer

摘　　要：目的探讨LLGL2蛋白在食管鳞癌组织中的表达及其临床意义。方法选择100例食管鳞癌患者的组织标本和20例癌旁正常食管组织标本。分析癌组织中LLGL2蛋白阳性表达率与其临床病理参数的关系,并采用ROC曲线分析LLGL2蛋白表达的预测价值。结果癌组织LLGL2蛋白阳性表达率(42.00%)高于癌旁组织(P<0.05);LLGL2蛋白阳性表达率与淋巴结转移、TNM分期相关(P<0.05),与性别、年龄、分化程度、发病位置无关(P>0.05);LLGL2蛋白表达预测淋巴结转移AUC为0.617,95%CI为0.502~0.732,P<0.05,LLGL2蛋白阳性表达预测TNM分期AUC为0.702,95%CI为0.596~0.809,P<0.05。结论LLGL2蛋白在食管鳞癌组织中的表达与淋巴结转移和TNM分期密切相关,具有潜在的临床预测价值,提示其可能作为食管鳞癌的潜在生物标志物。Objective To investigate the expression and clinical significance of LLGL2 protein in esophageal squamous cell carcinoma(ESCC).Methods A total of 100 ESCC tissues and 20 adjacent normal esophageal tissues were collected.The relationship between the positive expression rate of LLGL2 protein in cancer tissues and its clinicopathological parameters was analyzed,and the predictive value of LLGL2 protein expression was analyzed by ROC curve.Results The positive expression rate of LLGL2 protein in cancer tissues(42.00%)was higher than that in adjacent tissues(P<0.05).The positive expression rate of LLGL2 protein was correlated with lymph node metastasis and TNM stage(P<0.05),but not with gender,age,differentiation degree and tumor location(P>0.05).The AUC of LLGL2 protein expression in predicting lymph node metastasis was 0.617(95%CI:0.502~0.732,P<0.05),and the AUC of LLGL2 protein expression in predicting TNM stage was 0.702(95%CI:0.596~0.809,P<0.05).Conclusion The expression of LLGL2 protein in ESCC tissues is closely related to lymph node metastasis and TNM staging,which has potential clinical predictive value,suggesting that it may be used as a potential biomarker for ESCC.

关 键 词：食管鳞癌 LLGL2 预测价值 

分 类 号：R735.1[医药卫生—肿瘤]