CEA、CA125、CA199对胃癌患者病灶转移的评估价值及与胃癌病理特征的关系  

The Value of CEA,CA125 and CA199 in Evaluating Lesion Metastasis in Patients with Gastric Cancer and Their Relationship with Pathological Features

作　　者：冯永利[1] 郑喜胜[1] 李博[1] FENG Yongli;ZHENG Xisheng;LI Bo(Nanyang Central Hospital,Nanyang,473000)

机构地区：[1]河南省南阳市中心医院,473000

出　　处：《实用癌症杂志》2025年第1期83-86,共4页The Practical Journal of Cancer

摘　　要：目的探讨癌胚抗原(CEA)、糖类抗原125(CA125)和糖类抗原199(CA199)对胃癌患者病灶转移的评估价值及与胃癌病理特征的关系。方法收集102例胃癌患者临床资料作为观察组,另外收集健康体检者39例作为对照组,比较观察组与对照组的一般资料及血清CEA、CA125、CA199水平。分析血清CEA、CA125、CA199水平与胃癌病理特征的关系。随访患者1年的病灶转移情况,比较转移组与未转移组的CEA、CA125、CA199水平,分析三者对胃癌患者病灶转移的评估价值。结果2组性别、年龄、体质量指数比较差异无统计学意义(P>0.05),观察组CEA、CA125、CA199水平均高于对照组,差异有统计学意义(P<0.05)。胃癌低分化患者CEA、CA125、CA199水平均高于高中分化患者,Ⅲ+Ⅳ期患者CEA、CA125、CA199水平均高于Ⅰ+Ⅱ期患者,差异有统计学意义(P均<0.001)。转移组CEA、CA125、CA199表达水平均高于未转移组,差异有统计学意义(P均<0.001)。CEA、CA125、CA199的预测阈值分别为11.485μg/L、42.580 kU/L、55.055 kU/L。CEA、CA125、CA199对胃癌远处转移预测的曲线下面积(AUC)分别为0.771、0.784、0.731,三者联合预测价值较高,AUC面积为0.928,灵敏度、特异度较高。结论低分化、Ⅲ+Ⅳ期、远处转移患者CEA、CA125、CA199水平较高,CEA、CA125、CA199水平与胃癌患者病理分期存在一定关系,三者联合对病灶转移的预测效能较好。Objective To investigate the evaluation value of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and carbohydrate antigen 199(CA199)in metastasis of gastric cancer patients and their relationship with pathological features.Methods Clinical data of 102 patients with gastric cancer were collected as the observation group,and 39 healthy subjects were collected as the control group.General data of CEA,CA125 and CA199 levels were compared between the observation group and the control group.The relationship between serum CEA,CA125,CA199 levels and pathological features of gastric cancer was analyzed.The patients were followed up for 1 year,and the difference of CEA,CA125 and CA199 levels between the metastatic group and the non-metastatic group was compared,and the evaluation value of the three in the patients with gastric cancer was analyzed.Results There was no statistical significance in gender,age and body mass index between the 2 groups(P>0.05).CEA,CA125 and CA199 levels in the observation group were higher than those in the control group,with statistical significance(P<0.05).The levels of CEA,CA125 and CA199 in patients with low differentiation of gastric cancer were higher than those in patients with high differentiation,and the levels of CEA,CA125 and CA199 in patients with stageⅢ+Ⅳwere higher than those with stageⅠ+Ⅱ,with statistical significance(P<0.001).The expression levels of CEA,CA125 and CA199 in metastasis group were higher than those in non-metastasis group,and the differences were statistically significant(P<0.001).The predicted thresholds for CEA,CA125 and CA199 were 11.485μg/L,42.580 kU/L and 55.055 kU/L,respectively.The area under the curve(AUC)of CEA,CA125 and CA199 for predicting distant metastasis of gastric cancer were 0.771,0.784 and 0.731,respectively.The combined prediction value of CEA,CA125 and CA199 was high,and the AUC area was 0.928,indicating high sensitivity and specificity.Conclusion The CEA,CA125 and CA199 levels were higher in patients with low differentiation

关 键 词：CEA CA125 CA199 胃癌 转移 相关性 

分 类 号：R735.2[医药卫生—肿瘤]