血糖变异性对宫颈癌患者术后盆腔淋巴囊肿发生的预测价值分析  

Predictive Value of Blood Glucose Variability for Postoperative Pelvic Lymphocyst in Patients with Cervical Cancer

作　　者：刘艳[1] 王文君 周欢 杨梦霞 LIU Yan;WANG Wenjun;ZHOU Huan(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2025年第1期117-120,125,共5页The Practical Journal of Cancer

摘　　要：目的探讨血糖变异性对宫颈癌患者术后盆腔淋巴囊肿发生的预测价值。方法采用前瞻性分析,纳入84例早期宫颈癌患者为研究对象,所有患者入院后行宫颈癌根治手术治疗,根据患者随访期间盆腔淋巴囊肿发生情况进行分组,统计宫颈癌患者临床资料,监测患者术后48 h内血糖变异系数(CV)、平均血糖波动幅度(MAGE)水平及血糖水平标准差(SDBG)水平,分析宫颈癌患者术后血糖变异与盆腔淋巴囊肿发生的关系,采用多因素Logistic回归分析宫颈癌患者术后盆腔淋巴囊肿发生的影响因素。并根据受试者工作特征曲线(ROC曲线),评价血糖变异情况对术后盆腔淋巴囊肿发生的预测价值。结果84例宫颈癌患者行根治术后有21例患者出现盆腔淋巴囊肿,发生率为25.00%;两组患者年龄、BMI、病理类型、术中出血量比较,差异无统计学意义(P>0.05);发生组FIGO分期、手术方式、淋巴结清除范围、CV、MAGE、SDBG水平与未发生组比较,差异有统计学意义(P<0.05);经多因素Logistic回归分析,结果显示,FIGO分期、手术方式、淋巴结清除范围、CV、MAGE、SDBG均是宫颈癌患者术后盆腔淋巴囊肿发生的独立影响因素(P<0.05);绘制ROC曲线,结果显示,CV、MAGE、SDBG值预测盆腔淋巴囊肿发生的AUC均>0.7,具有一定的预测价值。结论FIGO分期、手术方式、淋巴结清除范围、血糖变异情况均是宫颈癌患者术后盆腔淋巴囊肿发生的独立因素,且患者术后血糖变异性对术后盆腔淋巴囊肿的发生具有一定预测价值,临床需控制宫颈癌术后患者血糖波动情况,减少术后盆腔淋巴囊肿的发生。Objective To explore the predictive value of blood glucose variability on the occurrence of pelvic lymphatic cysts in patients with cervical cancer after surgery.Methods A prospective analysis was used and included 84 early cervical cancer patients as the study subjects.After admission,all patients underwent radical cervical cancer surgery and were divided into groups based on the occurrence of pelvic lymphatic cysts during the follow-up period.The clinical data of patients with cervical cancer were collected,and the blood glucose variation coefficient(CV),mean amplitude of glycemic excursions(MAGE)and standard deviation of blood glucose(SDBG)were monitored within 48 hours after operation.The relationship between postoperative blood glucose variation and pelvic lymphatic cyst in patients with cervical cancer was analyzed.Multivariate Logistic regression analysis was used to investigate the influencing factors of postoperative pelvic lymphatic cysts in cervical cancer patients.According to the receiver operating characteristic curve(ROC curve),the predictive value of blood glucose variation on the occurrence of postoperative pelvic lymphatic cyst was evaluated.Results After radical surgery,21 out of 84 patients with cervical cancer developed pelvic lymphatic cysts,with an incidence rate of 25.00%.There was no statistical significant difference in age,BMI,pathological type,and intraoperative bleeding between the 2 groups of patients(P>0.05).The FIGO staging,surgical method,lymph node clearance range,CV,MAGE,and SDBG levels in the occurrence group were statistically significant compared to the non occurrence group,with a statistical significant difference(P<0.05).After multiple Logistic regression analysis,the results showed that FIGO staging,surgical method,lymph node clearance range,CV,MAGE,and SDBG were all independent influencing factors for the occurrence of pelvic lymph cyst in cervical cancer patients after surgery(P<0.05).The ROC curve was drawn.The results showed that the AUC of CV,MAGE and SDBG values in p

关 键 词：宫颈癌 术后 盆腔淋巴囊肿 血糖变异性 预测 

分 类 号：R737.33[医药卫生—肿瘤]