基于DSA的射频消融术联合TACE介入手术对肝癌近期疗效及并发症的影响  

Effect of DSA-based Radiofrequency Ablation and TACE Interventional Surgery on the Short-term Efficacy and Complications of Hepatocellular Carcinoma

作　　者：韩霜 肖博[1] 候仕莺 孙晶晶 HAN Shuang;XIAO Bo;HOU Shiying(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2025年第1期147-150,155,共5页The Practical Journal of Cancer

摘　　要：目的探究基于数字减影血管造影(DSA)的射频消融术(RFA)联合经肝动脉化疗栓塞(TACE)介入手术对肝癌近期疗效及并发症的影响。方法收集肝癌患者96例,依照治疗方法的不同进行分组,TACE介入手术治疗的42例为对照组,DSA的射频消融术联合TACE介入手术治疗的54例为观察组。比较AFP、CEA水平、免疫功能相关指标、并发症及1年生存率。结果干预前对照组的AFP、CEA水平与观察组水平差异无统计学意义(t=0.152,P=0.879;t=0.392,P=0.696);干预3个月后,2组AFP、CEA水平均降低,且观察组显著低于对照组(t=4.040,P=0.000;t=2.380,P=0.019)。干预前对照组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)与观察组水平差异无统计学意义(t=0.753,P=0.453;t=1.351,P=0.180;t=1.506,P=0.135);干预后的2组免疫相关指标水平均提升(t=6.452,P=0.000;t=19.341,P=0.000;t=52.677,P=0.000)、(t=2.851,P=0.007;t=14.680,P=0.000;t=32.192,P=0.000),且观察组高于对照组,差异有统计学意义(t=3.176,P=0.002;t=4.351,P=0.000;t=2.352,P=0.021)。对照组的并发症发生率与观察组相比(28.57%vs 18.52%),差异无统计学意义(χ^(2)=1.352,P=0.245)。观察组1年的生存率为90.74%,对照组为73.81%,差异有统计学意义(χ^(2)=4.876,P=0.027)。结论基于DSA的RFA联合TACE介入手术可有效治疗肝癌,患者1年生存率较高,并发症较少。Objective To investigate the effects of radiofrequency ablation(RFA)based on digital subtraction angiography(DSA)and transhepatic arterial chemoembolization(TACE)on the short-term efficacy and complications of hepatocellular carcinoma.Methods A total of 96 patients with liver cancer were collected and divided into groups according to different treatment methods.42 cases were treated with TACE interventional surgery as control group,and 54 cases were treated with DSA radiofrequency ablation and TACE interventional surgery as observation group.AFP,CEA levels,immune function related indexes,complications and 1-year survival rate were compared.Results Before intervention,there were no significant differences in AFP and CEA levels between control group and observation group(t=0.152,P=0.879;t=0.392,P=0.696).After 3 months of intervention,AFP and CEA levels were decreased in both groups,and the observation group was significantly lower than the control group(t=4.040,P=0.000;t=2.380,P=0.019).Before intervention,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in control group were not significantly different from those in observation group(t=0.753,P=0.453;t=1.351,P=0.180;t=1.506,P=0.135).After intervention,immunity-related indexes in both groups were increased(t=6.452,P=0.000;t=19.341,P=0.000;t=52.677,P=0.000),(t=2.851,P=0.007;t=14.680,P=0.000;t=32.192,P=0.000),and(t=2.851,P=0.007;t=14.680,P=0.000;t=32.192,P=0.000).The observation group was significantly higher than the control group(t=3.176,P=0.002;t=4.351,P=0.000;t=2.352,P=0.021).The complication rate of the control group was not significantly different from that of the observation group(28.57%vs18.52%)(χ^(2)=1.352,P=0.245).The 1-year survival rate was 90.74%in the observation group and 73.81%in the control group,with significant difference(χ^(2)=4.876,P=0.027).Conclusion RFA and TACE interventional surgery based on DSA can effectively treat liver cancer,with higher 1-year survival rate and fewer complications.

关 键 词：DSA 射频消融术 TACE 介入手术 肝癌 疗效 并发症 

分 类 号：R735.7[医药卫生—肿瘤]