免疫组化分子标志在蕈样肉芽肿中的应用价值  

Application of immunohistochemical markers in mycosis fungoides

作　　者：邵开心 刘向君 唐真真 SHAO Kaixin;LIU Xiangjun;TANG Zhenzhen(Leling People′s Hospital,Leling 253600,China;Qilu Hospital of Shandong University,Jinan 250000,China;Lanling People′s Hospital,Lanling 277700,China)

机构地区：[1]乐陵市人民医院,山东乐陵253600 [2]山东大学齐鲁医院,山东济南250000 [3]兰陵县人民医院,山东兰陵277700

出　　处：《皮肤性病诊疗学杂志》2025年第1期56-63,共8页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：蕈样肉芽肿(MF)是皮肤T细胞淋巴瘤最常见的亚型,多数MF病程进展缓慢且预后良好,但仍有部分早期患者可能出现疾病的进展,预后较差。免疫组织化学(IHC)染色作为一种临床较为常用的诊断手段,常见的标志分子如CD4、CD8、CD20、CD30等在蕈样肉芽肿中呈现不同的表达模式。此外,这些分子标志还可用于评估疾病的进展程度及预后。对免疫组化分子标志的深入研究有助于更好地理解MF的发病机制,为临床治疗提供更精准的依据,如指导治疗方案的选择及判断治疗效果等,在MF的临床管理中发挥着不可或缺的作用。本文综述IHC染色分子标志物对MF诊断及预后的作用,探索不同分子标志模式的应用价值。Mycosis fungoides(MF)is the most common subtype of cutaneous T-cell lymphomas.Most cases of MF progress slowly with a good prognosis.However,some early-stage patients may still experience disease progression with a poor prognosis.Immunohistochemical(IHC)staining is a commonly used diagnostic method in clinical practice.Common markers such as CD4,CD8,CD20,and CD30 have different expression patterns in mycosis fungoides.In addition,these markers can also be used to evaluate the degree of disease progression and prognosis.In-depth research on immunohistochemical markers helps better understand the pathogenesis of MF and provides a more accurate basis for clinical treatment,such as guiding the selection of treatment regimens and evaluating treatment effects,in addition to its indispensable role in the clinical management of MF.This article reviews the role of IHC markers in the diagnosis and prognosis of MF and explores the application value of different molecular marker patterns.

关 键 词：皮肤T细胞淋巴瘤 蕈样肉芽肿 免疫组织化学染色 预后 

分 类 号：R73[医药卫生—肿瘤]