牙发育的单细胞时空图谱——进展与展望  

Single-cell spatiotemporal atlas of tooth development:progress and prospects

作　　者：李雪纯 吴晓珊[1] Li Xuechun;Wu Xiaoshan(The Stomatology Center and Research Center of Oral and Maxillofacial Development and Regeneration of Xiangya Hospital,Academician Workstation for Oral&Maxillofacial Regenerative Medicine,Central South University,Changsha410008,China)

机构地区：[1]中南大学湘雅医院口腔医学中心,口腔颌面部发育与再生研究中心,中南大学口腔颌面再生王松灵院士工作站,长沙410008

出　　处：《中华口腔医学杂志》2025年第1期26-32,共7页Chinese Journal of Stomatology

基　　金：国家自然科学基金(82370917,82401054)。

摘　　要：单细胞结合空间多组学技术可以对不同状态下组织器官成千上万的细胞同时进行转录组、染色质开放状态等信息进行解析,并描述其空间定位。近年来,得益于单细胞多组学技术的发展,牙发育过程中各细胞亚型的定义、功能、演化和相互作用取得了许多重要进展。本文对已经发表的几篇牙发育单细胞多组学文章进行总结介绍,阐明单细胞多组学在推动牙发育研究中的作用,并对未来牙发育组学的研究前景进行展望。Single-cell and spatial multi-omics technologies enable the simultaneous analysis of thousands of cells in various states,revealing their transcriptional profiles,chromatin accessibility,and spatial positioning.Recent advances in single-cell multi-omics have led to significant discoveries regarding the definition,function,evolution,and interaction of various cell subtypes during tooth development.We summarize key findings from recent single-cell multi-omics studies on tooth development,highlighting their contributions to the field and discussing future perspectives in dental developmental genomics research.

关 键 词：基因组学 牙发育 单细胞测序 空间转录组测序 

分 类 号：R78[医药卫生—口腔医学]