钙离子转运在牙生物矿化中作用的研究进展  

Progress in research on the role of calcium ion transport in dental biomineralization

作　　者：刘奇奇 杨德琴 Liu Qiqi;Yang Deqin(Department of Endodontics,the Affiliated Stomatological Hospital of Chongqing Medical University,Chongqing 401147,China;Department of Operative Dentistry and Endodontics,Shanghai Stomatological Hospital&School of Stomatology,Fudan University&Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases,Fudan University,Shanghai 201602,China)

机构地区：[1]重庆医科大学附属口腔医院牙体牙髓科,重庆401147 [2]复旦大学附属口腔医院/上海市口腔医院牙体牙髓科,上海市颅颌面发育与疾病重点实验室,上海201602

出　　处：《中华口腔医学杂志》2025年第1期81-87,共7页Chinese Journal of Stomatology

基　　金：国家自然科学基金(32270888, 31970783);重庆医科大学特聘教授拔尖人才项目(重医大发2021(215));复旦大学附属口腔医院引进人才科研启动经费(SSDC-2024-RC08)

摘　　要：牙齿发育通过上皮组织和间充质组织之间相互作用而形成,是一个复杂的生物矿化过程。Ca^(2+)转运通道是这一过程的内在调节机制,在时间和空间上调节细胞内外Ca^(2+)的浓度,进而影响多种细胞的生物学功能以及细胞外羟基磷灰石的生长。本文就近年来Ca^(2+)转运对牙齿生物矿化及相应细胞发育影响的研究进行综述,以期为牙发育缺陷的预防、辅助临床早期诊断和改进治疗手段提供思路和依据。Tooth development is a complex biomineralization process formed through the interaction between epithelial tissue and mesenchymal tissue.The Ca^(2+)transport channel is the intrinsic regulatory mechanism of this process,which regulates the concentration of Ca^(2+) inside and outside the cell in time and space,thereby affecting the biological functions of various cells and the growth of extracellular hydroxyapatite.This article reviews the researches on the effects of Ca^(2+) transport in tooth biomineralization and corresponding cell development in recent years,with the aim of providing ideas and basis for the prevention of tooth developmental defects,assisting in early clinical diagnosis,and improving treatment methods.

关 键 词：牙釉质 牙发育 Ca 2+转运通道 生物矿化 细胞 牙本质 

分 类 号：R78[医药卫生—口腔医学]