Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC  

作　　者：Wenbin Zhou Yafei Gao Xinyu Feng Yanqing Zhang Cong Yang Lanxi He Fenghe Zhang Xiaoguang Li Qing Li 

机构地区：[1]School and Hospital of Stomatology,Cheeloo College of Medicine,Shandong University,Ji’nan 250012,China [2]China&Shandong Key Laboratory of Oral Tissue Regeneration,Ji’nan 250012,China [3]China&Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration,Ji’nan 250012,China [4]Department of Stomatology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Ji’nan 250021,China

出　　处：《Chinese Chemical Letters》2025年第1期392-396,共5页中国化学快报(英文版)

基　　金：supported by the National Natural Science Foundation of China(No.81802709);the Shandong Provincial Natural Science Foundation,China(Nos.ZR2023MH230,ZR2023MH096);the Shandong Provincial Postdoctoral Innovative Talents Funded Scheme;Plan of Young Scholars of Shandong University。

摘　　要：Immunotherapy offers significant potential but is often hampered by the immunosuppressive environment in oral squamous cell carcinoma(OSCC).To address this,we propose an enhanced immunotherapeutic strategy that revitalizes the tumor immune microenvironment(TIME)in OSCC by integrating upconversion-based photodynamic therapy(PDT)with chemotherapy.Using a red blood cell membraneinspired biomimetic nanoplatform,our approach concurrently delivers chlorin e6@upconversion nanoparticles(Ce6@UCNP)and doxorubicin(DOX).By leveraging fluorescence resonance energy transfer(FRET)for 980 nm to 660 nm upconversion excitation,we address challenges such as limited tissue penetration and tissue damage,as well as nanoplatform issues including immunogenicity and targeting inaccuracy Our integrated approach enhances PDT and chemotherapy with the goal of transforming immunologically“cold”tumors into“hot”ones through a cascaded therapy,thereby revitalizing the tumor immune microenvironment in OSCC.

关 键 词：Biomimetic nanoplatform UCNP-PDT CHEMOTHERAPY TIME OSCC 

分 类 号：R730.5[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]