老年急性脑梗死患者血清GSK-3β、CX3CR1水平与神经功能和预后的相关性分析  

Correlation analysis of serum levels of GSK-3βand CX3CR1 with neurological function and prognosis in elderly patients with acute cerebral infarction

作　　者：时伟 戴胜燕 张立娜 马艳 纪利利 郭书琴[1] SHI Wei;DAI Shengyan;ZHANG Li'na;MA Yan;JI Lili;GUO Shuqin(Department of Neurology,Baoding Second Central Hospital,Baoding Hebei 072750,China)

机构地区：[1]保定市第二中心医院神经内科,河北保定072750

出　　处：《中国急救复苏与灾害医学杂志》2025年第2期238-241,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：保定市科技计划项目(编号:2141ZF024)。

摘　　要：目的探讨老年急性脑梗死患者血清糖原合成激酶3β(GSK-3β)、CX3C趋化因子受体-1(CX3CR1)水平与神经功能和预后的相关性。方法收集2021年7月—2022年7月在本院就诊的老年急性脑梗死患者130例为观察组,同时选取在本院体检的健康者130例为对照组,观察组根据神经功能缺损量表评分(NIHSS)情况分为轻症组和重症组。Spearman等级法分析不同神经功能损伤程度与血清GSK-3β,CX3CR1表达水平的相关性;Logistic回归分析老年急性脑梗死患者预后的影响因素;受试者工作特征(ROC)曲线分析血清GSK-3β,CX3CR1水平对老年急性脑梗死患者预后的诊断价值。结果与健康对照组相比,观察组血清GSK-3β,CX3CR1水平显著升高(t=7.962、8.735,P<0.05);重症组血清GSK-3β、CX3CR1水平显著高于轻症组(t=2.478、2.633,P=0.015、0.010);NIHSS评分与血清GSK-3β,CX3CR1水平均呈正相关(r=0.533、0.497,P<0.05);Logistic回归分析结果显示,NIHSS评分、血清GSK-3β和CX3CR1水平均可作为影响老年急性脑梗死患者预后的独立危险因素(P<0.05);ROC曲线分析得出,血清GSK-3β、CX3CR1诊断老年急性脑梗死患者预后的曲线下面积(AUC)分别为0.852、0.829,联合诊断的AUC为0.933,优于二者单独诊断(P<0.05)。结论老年急性脑梗死患者血清GSK-3β、CX3CR1水平显著升高,且与患者神经功能损伤密切相关,GSK-3β和CX3CR1二者联合检测对患者预后有较高的诊断价值。Objective To investigate the correlation between serum levels of glycogen synthesis kinase-3β(GSK-3β)and CX3C chemokine receptor-1(CX3CR1)in elderly patients with acute cerebral infarction and neurological function and prognosis.Methods From July 2021 to July 2022,130 elderly patients with acute cerebral infarction who visited our hospital were regarded as the observation group,while 130 healthy individuals who underwent physical examination were regarded as the control group,the observation group was separated into mild group and severe group based on the National Institutes of Health Stroke Scale(NIHSS)score.Spearman rank method was applied to analyze the correlation between different degrees of neurological damage and the serum expression levels of GSK-3βand CX3CR1;Logistic regression was applied to analyze the influencing factors of prognosis in elderly patients with acute cerebral infarction;receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of serum GSK-3βand CX3CR1 levels for the prognosis of elderly patients with acute cerebral infarction.Results Compared with the healthy control group,the serum levels of GSK-3βand CX3CR1 in the observation group were obviously increased(t=7.962,8.735,P<0.05),the serum levels of GSK-3βand CX3CR1 in the severe group were obviously higher than those in the mild group(t=2.478,2.633,P=0.015,0.010);the NIHSS score was positively correlated with serum GSK-3βand CX3CR1 levels(correlation coefficient r values was 0.533 and 0.497,respectively,P<0.05);the results of Logistic regression analysis showed that NIHSS score,serum GSK-3β,and CX3CR1 levels were independent risk factors affecting the prognosis of elderly patients with acute cerebral infarction(P<0.05);ROC curve analysis showed that the area under the curve(AUC)of serum GSK-3βand CX3CR1 in the diagnosis of elderly acute cerebral infarction patients was 0.852 and 0.829,respectively,and the AUC of combined diagnosis was 0.933,which was better than the diagnosis of the two alone(P<0

关 键 词：老年人 急性脑梗死 糖原合成激酶3β CX3C趋化因子受体-1 神经功能 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学]