阿尔茨海默病防治研究面临的机遇与挑战  

The opportunities and challenges on prevention and control of Alzheimer′s disease

作　　者：张恒 仇成轩 杜怡峰 Zhang Heng;Qiu Chengxuan;Du Yifeng(Department of Neurology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China;Aging Research Center,Department of Neurobiology,Care Sciences and Society Karolinska Institutet-Stockholm University,Stockholm 17177,Sweden)

机构地区：[1]山东第一医科大学附属省立医院神经内科,济南250021 [2]Aging Research Center,Department of Neurobiology,Care Sciences and Society Karolinska Institutet-Stockholm University,Stockholm17177,Sweden

出　　处：《中华神经科杂志》2025年第1期10-16,共7页Chinese Journal of Neurology

摘　　要：阿尔茨海默病(AD)是一项重大的公共卫生挑战,已成为中国城乡居民的第5大死因,目前尚无针对该疾病的治愈性疗法。尽管近年来该疾病的诊疗技术取得了重大进展,但由于AD的异质性及其复杂的发病机制,该疾病的精准识别与干预仍存在着较大的局限和挑战,需要转变诊疗范式并专注于AD痴呆前期阶段这一“窗口”以取得突破。本文基于MIND-CHINA讨论AD的病因学、早期预警、风险评估、诊断方法及干预研究,以期制订符合我国国情的AD防治策略,并通过多角度分析目前在AD诊断、防治方面的局限和挑战,以促进迈向AD精准化医疗的未来。Alzheimer′s disease(AD)is a major public health challenge with no curative treatment at present and has become the fifth leading cause of death for urban and rural residents in China.Although diagnostic technology has made significant progress in recent years,precise identification of AD still faces certain limitations and challenges due to its heterogeneity and complex pathogenesis.It is possible to shift the paradigm and focus on the key"window"of the early stage of AD dementia to achieve breakthroughs.This article is based on MIND-CHINA(randomized controlled Multimodal INterventions to delay Dementia and disability in rural China)to discuss the etiology,prediction,risk-factors assessment,diagnosis,and intervention research of AD,in order to develop AD prediction and prevention strategies that are in line with China′s national conditions,and make a multi-perspective analysis of the current limitations and challenges on AD diagnosis and prevention to promote the future of precision medicine for AD.

关 键 词：阿尔茨海默病 预防 治疗 MIND-CHINA 

分 类 号：R749.16[医药卫生—神经病学与精神病学]