定量脑电图监测联合血清CXC趋化因子16、正五聚蛋白3对急性脑梗死患者预后的预测价值  

Prognostic value of quantitative electroencephalography monitoring combined with serum CXC chemokine 16 and pentametin 3 in acute cerebral infarction

作　　者：陈敏 王兴[2] 孙明[3] Chen Min;Wang Xing;Sun Ming(Jinzhou Medical University Graduate Training Base,Jinzhou 121000,China;Department of General Surgery,Jiangmen Central Hospital,Jiangmen 529030,China;Department of Neurology,Dandong Central Hospital,Dandong 118002,China;Department of Electrophysiology,Jiangmen Central Hospital,Jiangmen 529030,China)

机构地区：[1]锦州医科大学研究生培养基地,锦州121000 [2]江门市中心医院普外科,江门529030 [3]丹东市中心医院神经内科,丹东118002 [4]江门市中心医院电生理科,江门529030

出　　处：《中国医师进修杂志》2025年第2期112-115,共4页Chinese Journal of Postgraduates of Medicine

基　　金：江门市医疗卫生领域科技计划项目(2021YL01005)。

摘　　要：目的探讨定量脑电图监测联合血清CXC趋化因子16(CXCL16)、正五聚蛋白3(PTX3)对急性脑梗死患者预后的预测价值。方法回顾性选取2018年3月至2023年3月江门市中心医院收治的急性脑梗死患者110例为研究对象,出院90 d时通过改良Rankin量表(mRs)评分对患者预后情况进行评估并分组,其中预后良好组75例,预后不良组35例,比较两组入院时定量脑电图监测指标和血清CXCL16、PTX3水平。采用受试者工作特征(ROC)曲线分析联合诊断对急性脑梗死患者预后不良的诊断效能。结果预后不良组血清CXCL16、PTX3水平高于预后良好组[(3.74±0.59)μg/L比(2.58±0.41)μg/L、(3.36±0.67)μg/L比(3.01±0.52)μg/L],差异有统计学意义(P<0.05)。预后不良组各脑区功率比指数(DTABR)及总体DTABR均高于预后良好组,差异有统计学意义(P<0.05)。ROC曲线分析结果显示,定量脑电图监测联合血清CXCL16、PTX3预测急性脑梗死患者预后不良的曲线下面积为0.911(95%CI 0.849~0.974),高于任一单项指标(P<0.05)。结论急性脑梗死预后不良患者血清CXCL16、PTX3水平及定量脑电图监测指标DTABR均高于预后良好患者,三项指标联合监测对急性脑梗死患者预后不良具有较高的预测价值。Objective To analyze the prognostic value of quantitative electroencephalography(EEG)monitoring combined with serum CXC chemokine 16(CXCL16)and pentametin 3(PTX3)in acute cerebral infarction.Methods A total of 110 patients with acute cerebral infarction admitted to Jiangmen Central Hospital from March 2018 to March 2023 were retrospectively selected as the study objects,at 90 d after discharge,the prognosis of the patients was assessed by the modified Rankin Scale(mRs)score and divided into two groups,including 75 cases in the good prognosis group and 35 cases in the poor prognosis group.Quantitative EEG monitoring indexes and serum CXCL16 and PTX3 levels were compared between the two groups at admission.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy for poor prognosis in patients with acute cerebral infarction.Results The levels of CXCL16 and PTX3 in the poor prognosis group were higher than those in the good prognosis group:(3.74±0.59)μg/L vs.(2.58±0.41)μg/L,(3.36±0.67)μg/L vs.(3.01±0.52)μg/L,there were statistical differences(P<0.05).Compared with patients with good prognosis in acute cerebral infarction,the power ratio index(DTABR)level of the quantitative EEG monitoring index were higher than those in patients with a poor prognosis(P<0.05).ROC curve analysis showed that the area under the curve of quantitative EEG monitoring combined with serum CXCL16,and PTX3 for predicting poor prognosis in patients with acute cerebral infarction was 0.911(95%CI 0.849-0.974),which was higher than any single index(P<0.05).Conclusions The levels of DTABR,serum CXCL16 and PTX3 in patients with a poor prognosis of acute cerebral infarction were higher than those in patients with good prognosis.Quantitative EEG monitoring combined with serum CXCL16 and PTX3 had high predictive value for poor prognosis of acute cerebral infarction.

关 键 词：脑梗死 脑电描记术 CXC趋化因子16 五聚蛋白3 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学]