天然药物靶向铁死亡缓解脑缺血再灌注损伤的研究进展  

Research advances of natural drugs targeting ferroptosis to alleviate cerebral ischemia reperfusion injury

作　　者：侯悦茹 吴刚[2] 罗振国 Hou Yueru;Wu Gang;Luo Zhenguo(The Second Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang 712046,China;Department of Anesthesiology,Honghui Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710054,China)

机构地区：[1]陕西中医药大学第二临床医学院,咸阳712046 [2]西安交通大学附属红会医院麻醉科,西安710054

出　　处：《国际麻醉学与复苏杂志》2024年第12期1340-1344,共5页International Journal of Anesthesiology and Resuscitation

基　　金：西安市创新能力强基计划‑医学研究项目(22YXYJ0019)。

摘　　要：脑缺血再灌注损伤(CIRI)是一个复杂的病理过程,目前临床缺乏有效的治疗措施。铁死亡是一种不同于凋亡、坏死和自噬的新型细胞死亡方式,胞内铁过载和脂质过氧化物积累是主要特征。目前研究表明铁死亡参与心脏疾病、肿瘤和卒中等多种疾病的发生、发展。天然药物具有多生物活性、多作用靶点的特点,靶向铁死亡的天然药物为CIRI的治疗提供了新方案,成为CIRI治疗的新热点。文章综述了铁死亡在CIRI中的机制,探讨天然药物、天然药物提取物及混合物干预铁死亡不同环节缓解CIRI的研究现状,以期为缓解CIRI提供新思路和新方法。Cerebral ischemia reperfusion injury(CIRI)is a complex pathological process that currently lacks effective clinical treatments.Ferroptosis represents a distinct form of programmed cell death,differing from apoptosis,necrosis,and autophagy.It is characterized by the accumulation of iron and lipid peroxides.Recent research has demonstrated the involvement of ferroptosis in the development of various diseases,including heart disease,tumors,and stroke.Natural compounds exhibit multiple biological activities and target various pathways.Consequently,natural compounds that target ferroptosis present a novel therapeutic approach for CIRI,emerging as a prominent area of investigation.This review examines the mechanisms underlying ferroptosis in CIRI and discusses the current research status of natural compounds,extracts,and combinations that intervene at different stages of ferroptosis to alleviate this condition.The aim is to provide new insights and methodologies for mitigating CIRI.

关 键 词：铁死亡 脑缺血再灌注损伤 天然药物 

分 类 号：R73[医药卫生—肿瘤]