精神分裂症患者中医体质与复发先兆症状网络分析  

Network analysis of constitution of traditional Chinesemedicine and prodromal symptoms of relapsein schizophrenia patients

作　　者：谭碧璨 蒋小剑[1] 邹书亭 朱正敏 葛盈琼 欧阳小双 夏宝娟 李川 TAN Bican;JIANG Xiaojian;ZOU Shuting;ZHU Zhengmin;GE Yingqiong;OUYANG Xiaoshuang;XIA Baojuan;LI Chuan(Nursing College of Hunan University of Chinese Medicine,Changsha,Hunan,410208;Hunan Brain Hospital,Changsha,Hunan,410007)

机构地区：[1]湖南中医药大学护理学院,湖南长沙410208 [2]湖南省脑科医院,湖南长沙410007

出　　处：《实用临床医药杂志》2025年第1期112-117,共6页Journal of Clinical Medicine in Practice

基　　金：2023年度湖南省社会科学成果评审委员会课题成果(XSP2023GLC121);湖南省教育科学“十四五”规划2023年度课题(XJK23BGD014);湖南省中医药管理局科研计划项目(B2023123)。

摘　　要：目的 采用网络分析法识别精神分裂症患者的核心体质和复发先兆症状,分析二者的关系及性别差异。方法 选取2022年10月—2023年12月在湖南省脑科医院精神科住院治疗的精神分裂症患者作为调查对象,应用一般资料调查表、中医体质量表、精神分裂症复发先兆量表对其进行调查,采用R语言进行网络分析。结果 精神分裂症患者的核心体质为气虚质[期望影响(EI)=1.08]和湿热质(EI=1.00),核心复发先兆症状为抑郁/退缩(EI=0.84)和初始的精神病性表现(EI=0.81)。不同性别患者中医体质与复发先兆症状差异有统计学意义(P<0.05),女性患者中医体质以气虚质(EI=1.20)为主,复发先兆症状以焦虑(EI=0.98)为核心,男性患者以阴虚质(EI=1.05)为主,复发先兆症状以抑郁/退缩(EI=1.00)为核心。结论 医护人员可通过精神分裂症患者的核心偏颇体质,早期识别核心复发先兆症状,并制订精准化干预策略,从而促使患者网络结构改变,预防疾病复发,提高患者的生活质量。Objective To identify the core constitutions and prodromal symptoms of relapse in schizophrenia patients using network analysis,and to analyze their relationships as well as gender differences.Methods Schizophrenia patients hospitalized in the psychiatry department of Hunan Brain Hospital in Hunan Province between October 2022 and December 2023 were selected as survey participants.A general information questionnaire,a Traditional Chinese Medicine Constitution Scale,and a Schizophrenia Prodromal Symptoms of Relapse Scale were used for investigation.Network analysis was conducted using R language.Results The core constitutions of schizophrenia patients were qi deficiency constitution[Expected Influence(EI)=1.08]and dampness-heat constitution(EI=1.00),and the core prodromal symptoms of relapse were depression/withdrawal(EI=0.84)and initial psychotic manifestations(EI=0.81).There were statistically significant differences in constitutions of traditional Chinese medicine and prodromal symptoms of relapse between patients of different genders(P<0.05).Females mainly exhibited qi deficiency constitution(EI=1.20)with anxiety as the core prodromal symptom(EI=0.98),while males mainly exhibited yin deficiency constitution(EI=1.05)with depression/withdrawal as the core prodromal symptom(EI=1.00).Conclusion Healthcare professionals can early identify core prodromal symptoms of relapse by core imbalanced constitutions of schizophrenia patients,and develop precise intervention strategies,thereby promoting changes in their network structure, preventing disease relapse, and improving patients′ quality of life.

关 键 词：精神分裂症 中医体质 复发先兆症状 网络分析 复发 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R241[医药卫生—临床医学] R49